121083-41-8Relevant academic research and scientific papers
Identification of an indole series of prostaglandin D2 receptor antagonists
Sturino, Claudio F.,Lachance, Nicolas,Boyd, Michael,Berthelette, Carl,Labelle, Marc,Li, Lianhai,Roy, Bruno,Scheigetz, John,Tsou, Nancy,Brideau, Christine,Cauchon, Elizabeth,Carriere, Marie-Claude,Denis, Danielle,Greig, Gillian,Kargman, Stacia,Lamontagne, Sonia,Mathieu, Marie-Claude,Sawyer, Nicole,Slipetz, Deborah,O'Neill, Gary,Wang, Zhaoyin,Zamboni, Robert,Metters, Kathleen M.,Young, Robert N.
, p. 3043 - 3048 (2008/09/21)
A novel indole series of PGD2 receptor (DP receptor) antagonists is presented. Optimization of this series led to the identification of potent and selective DP receptor antagonists. In particular, antagonists 35 and 36 were identified with Ksu
Tetrahydrocarbazoles for the improvement of cyclosporin therapy
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, (2008/06/13)
Tetrahydrocarbazoles, especially Tetrahydrocarbazole-1-alkanoic acids are disclosed. The compounds are useful for improving cyclosporine therapy. In particular, the compounds are useful for limiting cyclosporine induced nephrotoxicity which comprises the
Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
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, (2008/06/13)
Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platlet aggregation, cerebral spasm, premature labor, spontaneous abortio
