1172048-20-2Relevant academic research and scientific papers
New S-adenosyl-L-methionine analogues: Synthesis and reactivity studies
Townsend, Andrew P.,Roth, Stefanie,Williams, Huw E. L.,Stylianou, Eleni,Thomas, Neil R.
supporting information; experimental part, p. 2976 - 2979 (2010/03/25)
Two new and complementary synthetic strategies for 5'-N-chloroethylamino- 5'-deoxyadenosines are presented. Additionally, the reaction kinetics of their conversion into aziridines under typical enzyme assay conditions is reported using time-resolved NMR spectroscopy. A stable photocaged derivative of 5'-N-chloroethylamino-5'-deoxyadenosine has also been synthesized, and its stability and activation in aqueous solution at physiological pH have been examined.
