1172136-06-9Relevant academic research and scientific papers
Transformations of 5-chloro-2-hydrazino-4-p-tolylsulfonyl-1,3-thiazole
Turov,Vinogradova,Drach
experimental part, p. 2132 - 2136 (2009/04/12)
Accessible 2,2-dichloro-1-p-tolylsulfonylethenyl isothiocyanate reacted with hydrazine hydrate to give 5-chloro-2-hydrazino-4-p-tolylsulfonyl-1,3- thiazole whose reactions with thiols and amines followed a complicated pattern. Treatment of 5-chloro-2-hydrazino-4-p-tolylsulfonyl-1,3-thiazole with acetylacetone led to the formation of previously unknown 5-chloro-2-(3,5- dimethyl-1H-pyrazol-1-yl)-4-p-tolylsulfonyl-1,3-thiazole which reacted with O-, S-, and N-centered nucleophiles at the C5 atom with high regioselectivity.
