117257-96-2Relevant academic research and scientific papers
SYNTHESIS OF 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE AND ITS ACTIVITY AGAINST HIV
Tolstikov, G. A.,Mustafin, A. G.,Gataullin, R. R.,Abdrakhmanov, I. B.,Plyasunova, A. G.,Pokrovskii, A. G.
, p. 113 - 115 (2007/10/02)
2,3-Didehydro-3'-deoxythymidine has been obtained with an overall yield of 10percent by the condensation of 1,2-di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose with bis(dimethylsilyl)thymine and a series of subsequent transformations.The anti-HIV activity of the compound obtained was studied on the model of MT-4 lymphoid cells primarily infected with HIV-1.It was found that the substance effectively inhibits the reproduction of HIV-1 in a cell culture.
Synthesis of β-D-xylofuranosyl- and 2,2'-anhydro-1-β-D-lyxofuranosylpyrimidine nucleosides
Tolstikov, G.A.,Mustafin, A.G.,Gataullin, R.R.,Spirikhin, L.V.,Sultanova, V.S.,Abdrakhmanov, I.B.
, p. 1095 - 1099 (2007/10/02)
β-D-Xylofuranosylpyrimidines were obtained by condensation of silyl derivatives of pyrimidines with 1,2-di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose with subsequent deprotection of the sugar fragment.Refluxing 2-O-tosyl derivatives of nucleosides with NaI
Nucleic acid related compounds. 53. Synthesis and biological evaluation of 2'-deoxy-&β-threo-pentofuranosyl nucleosides. "Reversion to starting alcohol" in Barton-type reductions of thionocarbonates
Robins, Morris J.,Madej, Danuta,Hansske, Fritz,Wilson, John S.,Gosselin, Gilles,et al.
, p. 1258 - 1262 (2007/10/02)
Treatment of selectively 3',5'-protected β-D-xylofuranosyl nucleosides (4) with phenyl chlorothionocarbonate and DMAP followed by hydrogenolysis of the resulting (2'-O-phenoxythiocarbonyl) phenyl thionocarbonate esters (6) with tributylstannane/AIBN, and
