1172637-87-4 Usage
General Description
The chemical 4,5,6,7-Tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4-phenyl-2-benzothiazolamine is a complex organic compound with a long and specific chemical structure. It contains a benzothiazolamine core with various substituents, including a methoxy group, a methyl-imidazol-1-yl group, and a phenyl group. 4,5,6,7-Tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4-phenyl-2-benzothiazolamine is likely to have diverse pharmacological properties due to its intricate structure, and it may be used in various research and pharmaceutical applications. The specific biological activities and potential uses of this compound would need to be further investigated through experimentation and analysis.
Check Digit Verification of cas no
The CAS Registry Mumber 1172637-87-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,2,6,3 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1172637-87:
(9*1)+(8*1)+(7*7)+(6*2)+(5*6)+(4*3)+(3*7)+(2*8)+(1*7)=164
164 % 10 = 4
So 1172637-87-4 is a valid CAS Registry Number.
1172637-87-4Relevant articles and documents
Aminothiazoles as γ-secretase modulators
Lübbers, Thomas,Flohr, Alexander,Jolidon, Synese,Jacobsen, Helmut,Ozmen, Laurence,Baumann, Karlheinz,David-Pierson, Pascale
, p. 6554 - 6558 (2011/12/04)
We herein report the discovery of a new γ-secretase modulator class with an aminothiazole core starting from a HTS hit (3). Synthesis and SAR of this series are discussed. These novel compounds demonstrate moderate to good in vitro potency in inhibiting amyloid beta (Aβ) peptide production. Overall c-secretase is not inhibited but the formation of the aggregating, toxic Aβ42 peptide is shifted to smaller non-aggregating Ab peptides. Compound 15 reduced brain Abβ42 in vivo in APPSwe transgenic mice at 30 mg/kg p.o.
