958245-18-6

Basic information

• Product Name: 3-methoxy-4-(4-methylimidazole)benzenamine
• Synonyms: 3-methoxy-4-(4-methylimidazole)benzenamine;3-Methoxy-4-(4-Methyl-1H-iMidazol-1-yl)benzenaMine;Benzenamine, 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-
• CAS NO: 958245-18-6
• Molecular Formula: C₁₁H₁₃N₃O
• Molecular Weight: 203.244
• Mol File: 958245-18-6.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 417.202°C at 760 mmHg
• Flash Point: 206.116°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-methoxy-4-(4-methylimidazole)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-4-(4-methylimidazole)benzenamine(958245-18-6)
• EPA Substance Registry System: 3-methoxy-4-(4-methylimidazole)benzenamine(958245-18-6)

Safety Data

• Hazardous Substances Data: 958245-18-6(Hazardous Substances Data)

Usage

Uses

3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzenamine is used in the synthesis of series of heterocycles as potent γ-secretase modulators (GSMs);Also, it is derived 4-Methylimidazole (M312990), which is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.

InChI:InChI=1/C11H13N3O/c1-8-6-14(7-13-8)10-4-3-9(12)5-11(10)15-2/h3-7H,12H2,1-2H3

Upstream product

• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 1009-36-5 2-chloro-5-nitroanisole 
• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 
• 958245-17-5 1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole 

Downstream Products

• 1077628-66-0 1-(4-isothiocyanato-2-methoxy-phenyl)-4-methyl-1H-imidazole 
• 1077628-80-8 [4-(4-chloro-phenyl)-thiazol-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine 
• 958245-19-7 phenyl N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-N-(phenoxycarbonyl)carbamate 
• 958245-22-2 phenyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbamate 
• 1185015-25-1 2-{6-ethoxy-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-pyrimidin-4-yl}-propan-2-ol 
• 1232039-32-5 C₂₁H₂₂N₆O₃ 
• 870838-56-5 1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole 
• 1262193-88-3 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride 
• 1315141-29-7 C₁₁H₁₁N₅O 
• 1452228-04-4 C₂₄H₂₉N₇O₃ 
• 1452228-06-6 C₂₁H₂₃N₇O₃ 
• 1452228-03-3 C₂₅H₂₉N₇O₂ 

Relevant articles and documents

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.

NOVEL SUBSTITUTED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the mean

Triazoles as γ-secretase modulators

Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for olefin