1172797-65-7

Usage

Pyrazole derivative

It is a five-membered heterocyclic ring with two nitrogen atoms at adjacent positions, which makes it a derivative of the pyrazole family of compounds.

Pharmaceutical industry application

1-methyl-5-cyclopropyl-pyrazole is commonly used in research and development in the pharmaceutical industry due to its potential pharmacological properties.

Building block in organic synthesis

The compound has been studied for its potential use as a building block in organic synthesis, which allows for the creation of more complex molecules and compounds.

Ligand in coordination chemistry

1-methyl-5-cyclopropyl-pyrazole can also serve as a ligand in coordination chemistry, which involves the formation of complexes between metal ions and organic molecules.

Versatile chemical

1-methyl-5-cyclopropyl-pyrazole is a versatile chemical with diverse potential applications in various scientific and industrial fields, making it a valuable asset in the realm of chemistry.

Upstream product

• 100114-57-6 3-cyclopropyl-1H-pyrazole 
• 485-80-3 S-adenosyl-L-methionine 
• 21666-68-2 (E)-1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one 
• 60-34-4 methylhydrazine 

Relevant academic research and scientific papers

Engineered Enzymes Enable Selective N-Alkylation of Pyrazoles With Simple Haloalkanes

Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst-controlled pyrazole alkylation by a cyclic two-enzyme cascade. In this enzymatic system, a promiscuous enzyme uses haloalkanes as precursors to generate non-natural analogs of the common cosubstrate S-adenosyl-l-methionine. A second engineered enzyme transfers the alkyl group in highly selective C?N bond formations to the pyrazole substrate. The cosubstrate is recycled and only used in catalytic amounts. Key is a computational enzyme-library design tool that converted a promiscuous methyltransferase into a small enzyme family of pyrazole-alkylating enzymes in one round of mutagenesis and screening. With this enzymatic system, pyrazole alkylation (methylation, ethylation, propylation) was achieved with unprecedented regioselectivity (>99 %), regiodivergence, and in a first example on preparative scale.

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES

Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.