21666-68-2

Basic information

• Product Name: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one
• Synonyms: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one;(E)-1-cyclopropyl-3-(diMethylaMino)prop-2-en-1-one;1-Cyclopropyl-3-(diMethylaMino)prop-2-en-1-one;(2Z)-1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one
• CAS NO: 21666-68-2
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.2
• Mol File: 21666-68-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 218.4°C at 760 mmHg
• Flash Point: 76.2°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 0.126mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one(21666-68-2)
• EPA Substance Registry System: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one(21666-68-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21666-68-2(Hazardous Substances Data)

Usage

General Description

1-cyclopropyl-3-(dimethylamino)-2-propen-1-one is a chemical compound with a unique molecular structure. It consists of a cyclopropyl ring attached to a propenone group, with a dimethylamino substituent located on the carbon adjacent to the carbonyl group. 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one has potential pharmacological and biological applications due to its diverse structural features. The cyclopropyl ring contributes to its rigidity, while the presence of the dimethylamino group can enhance its solubility and interactions with biological targets. As a result, 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one may be of interest for medicinal and synthetic chemistry research, with potential for use in the development of novel pharmaceuticals or biologically active compounds.

InChI:InChI=1/C8H13NO/c1-9(2)6-5-8(10)7-3-4-7/h5-7H,3-4H2,1-2H3

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1135283-57-6 5-bromo-6-cyclopropyl-2-hydroxynicotinonitrile 
• 957292-12-5 2-(3-cyclopropyl-1H-pyrazol-1-yl)acetic acid 
• 100114-57-6 3-cyclopropyl-1H-pyrazole 
• 902837-67-6 3-cyclopropyl-1-methyl-1H-pyrazole-4-carbaldehyde 
• 1053163-67-9 1-methyl-3-cyclopropylpyrazole 
• 1257637-82-3 3-cyclopropyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 187163-98-0 6-cyclopropyl-3-nitropyridin-2(1H)-one 
• 101045-94-7 6-Cyclopropyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1172797-65-7 1-methyl-5-cyclopropyl-pyrazole 
• 187164-01-8 (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid tert-butyl ester 
• 187164-02-9 (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid 

Relevant articles and documents

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes asC4units

An efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the CC bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standardC4units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a CC bond cleavage of the enaminone and insertion of a newC(sp2) source with the formation of two C-C single bonds. A broad range of substrates can be used to synthesize the corresponding 1,3-dienes under very mild reaction conditions, including low catalyst-loading, ambient temperature, and a neutral reaction solvent.

Preparation method of isoxazole herbicide intermediate

The invention relates to the field of chemical synthesis, particularly to a preparation method of an isoxazole herbicide intermediate, wherein the isoxazole herbicide intermediate is a compound represented by a formula (III) and is prepared by reacting a compound (I), a compound (II) and alkali in the presence of a solvent. The preparation method disclosed by the invention is simple, convenient, safe and high in conversion rate, can reduce the cost when being used for preparing the isoxazole herbicide, and is more economical and environment-friendly. The synthetic route is represented by the specification.

Preparation technology of 3-cyclopropyl-1-methyl-1H-pyrazole-4-formaldehyde

The invention provides a preparation technology of 3-cyclopropyl-1-methyl-1H-pyrazole-4-formaldehyde (compound 1). The preparation technology comprises the following steps: 1) 1-cyclopropyl methyl ketone reacts with N,N-dimethylformamide dimethylacetal in N,N-dimethylformamide solvent at a proper temperature to obtain a compound 2; 2) the compound 2 reacts with hydrazine hydrate react in an alcohol solvent at a reflux temperature to obtain a compound 3; 3) the compound 3 reacts with a methylation reagent at room temperature to obtain a compound 4; 4) the compound 3 reacts with N,N-dimethylformamide in a halohydrocarbon solvent in an ice-water bath, to obtain the 3-cyclopropyl-1-methyl-1H-pyrazole-4-formaldehyde (compound 1). The synthesis route is shown in the description. According to thepreparation technology provided by the invention, the adopted raw materials, reagents and solvents are conventional synthetic reagents which are cheap and easily available; the reaction conditions inall steps are mild, the aftertreatment is simple, the reaction yield is relatively high, and the product purity is high. Overall preparation cost of the product is low, and the requirements of industrial production are met.