117309-27-0

Basic information

• Product Name: 2-([(4-METHOXYPHENYL)SULFONYL]ANILINO)ACETIC ACID
• Synonyms: 2-([(4-METHOXYPHENYL)SULFONYL]ANILINO)ACETIC ACID;2-(N-phenyl4-methoxybenzenesulfonamido)acetic acid
• CAS NO: 117309-27-0
• Molecular Formula: C₁₅H₁₅NO₅S
• Molecular Weight: 321.35
• Mol File: 117309-27-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-([(4-METHOXYPHENYL)SULFONYL]ANILINO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([(4-METHOXYPHENYL)SULFONYL]ANILINO)ACETIC ACID(117309-27-0)
• EPA Substance Registry System: 2-([(4-METHOXYPHENYL)SULFONYL]ANILINO)ACETIC ACID(117309-27-0)

Safety Data

• Hazardous Substances Data: 117309-27-0(Hazardous Substances Data)

Usage

General Description

The chemical 2-([(4-METHOXYPHENYL)SULFONYL]ANILINO)ACETIC ACID, also known as Mefenamic acid, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce pain, inflammation, and fever. It works by inhibiting the production of certain chemicals in the body that cause inflammation and pain. Mefenamic acid is often prescribed for the treatment of menstrual cramps, arthritis, and other conditions that involve pain and inflammation. It is typically taken orally in the form of tablets or capsules and is available by prescription in many countries. As with all NSAIDs, Mefenamic acid can have side effects and interactions with other medications, so it should be used with caution and under the guidance of a healthcare professional.

Upstream product

• 103-01-5 N-Phenylglycine 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Relevant articles and documents

N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase

A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.