117309-41-8 Usage
Description
2-[4-CHLORO(PHENYLSULFONYL)ANILINO]ACETIC ACID is a chemical compound that belongs to the class of acetanilide derivatives. It is a white to off-white crystalline powder that is soluble in organic solvents but insoluble in water. 2-[4-CHLORO(PHENYLSULFONYL)ANILINO]ACETIC ACID is known for its non-opioid analgesic and anti-inflammatory properties, making it a valuable component in pharmaceutical formulations.
Uses
Used in Pharmaceutical Industry:
2-[4-CHLORO(PHENYLSULFONYL)ANILINO]ACETIC ACID is used as a non-opioid analgesic and anti-inflammatory medication for the treatment of various conditions. It is effective in managing pain and inflammation by inhibiting the production of certain chemicals in the body that cause these symptoms.
Used in Pain Management:
2-[4-CHLORO(PHENYLSULFONYL)ANILINO]ACETIC ACID is used as a pain reliever for conditions such as arthritis, menstrual cramps, and other types of pain. Its non-opioid nature makes it a safer alternative to opioids for long-term pain management.
Used in Inflammation Treatment:
2-[4-CHLORO(PHENYLSULFONYL)ANILINO]ACETIC ACID is used as an anti-inflammatory agent to reduce inflammation and associated discomfort. It is particularly useful in the treatment of conditions where inflammation plays a significant role, such as arthritis.
Check Digit Verification of cas no
The CAS Registry Mumber 117309-41-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,0 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 117309-41:
(8*1)+(7*1)+(6*7)+(5*3)+(4*0)+(3*9)+(2*4)+(1*1)=108
108 % 10 = 8
So 117309-41-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H12ClNO4S/c15-11-6-8-12(9-7-11)16(10-14(17)18)21(19,20)13-4-2-1-3-5-13/h1-9H,10H2,(H,17,18)/p-1
117309-41-8Relevant articles and documents
N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase
DeRuiter, Jack,Borne, Ronald F.,Mayfield, Charles A.
, p. 145 - 151 (2007/10/02)
A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.
