1173119-91-9

Upstream product

• 3848-36-0 4-chlorobenzaldoxime 
• 1066-54-2 trimethylsilylacetylene 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 

Downstream Products

• 14688-31-4 3-(4′-chlorophenyl)-5-(4′′-methylphenyl)isoxazole 
• 31301-39-0 3-(4-chlorophenyl)-isoxazole 
• 1048922-51-5 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid 
• 81963-65-7 2-(3-(4-chlorophenyl)isoxazol-5-yl)-1-phenylethan-1-one 

Relevant academic research and scientific papers

Rhodium(iii)-catalysed decarboxylative C-H functionalization of isoxazoles with alkenes and sulfoxonium ylides

Decarboxylative C-H functionalization of isoxazoles with electron-deficient alkenes and sulfoxonium ylides at the C5 position was achieved in the presence of rhodium(iii) catalysts to give the corresponding alkenylation and acylmethylation products, respe

Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position

A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.

Efficient synthesis of isoxazoles and isoxazolines from aldoximes using Magtrieve (CrO2)

Treatment of aldoximes 1 with Magtrieve (CrO2) in presence of dipolarophile 3 or 4, furnished a variety of isoxazolines 5a-u and isoxazoles 6a-q as 1,3-dipolar cycloaddition (1,3-DC) products (38 examples; 63-90% isolated yields). In situ formation of a nitrile oxide intermediate was confirmed through isolation of the dimerization product furoxane 2a in absence of any dipolarophile. The methodology has been extended to intramolecular nitrile oxide cycloaddition (INOC) reactions to access highly useful chromane derivatives 7-8 (75-80% isolated yields). Magtrieve, as a new reagent for 1,3-DC reactions, has offered excellent substrate generality and at the same time demonstrated tolerance toward sensitive protecting groups and electron-rich functional groups.