31301-39-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Chlorophenyl)isoxazole is used as a key intermediate in the synthesis of various pharmaceuticals for its potential therapeutic applications. The 4-chlorophenyl group attached to the isoxazole ring provides a structural foundation that can be further modified to create drugs with specific biological activities.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(4-Chlorophenyl)isoxazole is utilized as a building block for the development of new agrochemicals aimed at crop protection. Its chemical structure can be tailored to produce compounds with pesticidal properties, contributing to the enhancement of agricultural productivity and crop safety.
Used in Research and Development:
3-(4-Chlorophenyl)isoxazole also serves as a research chemical, facilitating the exploration and development of new drugs. Its unique structure allows scientists to investigate its interactions with biological targets, potentially leading to the discovery of new therapeutic agents.

Upstream product

• 89047-02-9 3-(4-Chloro-phenyl)-5-nitro-4,5-dihydro-isoxazole 
• 35167-28-3 vinyl phenyl selenide 
• 15500-74-0 4-chlorobenzonitrile N-oxide 
• 20451-53-0 Phenyl vinyl sulfoxide 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 3848-36-0 4-chlorobenzaldoxime 
• 14063-77-5 (Z)-3-chloro-3-(4-chlorophenyl)acrylaldehyde 
• 1075-77-0 4-chlorocinnamaldehyde 
• 1258507-15-1 3-(4-chlorophenyl)-5-(phenylthio)-2-isoxazoline 
• 1606167-99-0 C₁₄H₁₁ClNO⁽¹⁺⁾*Br^(1-) 
• 1173119-91-9 3-(4-chlorophenyl)-5-(trimethylsilanyl)isoxazole 
• 37614-57-6 3-(4-chlorophenyl)prop-2-yn-1-ol 
• 170648-35-8 3-(4-chlorophenyl)-5-hydroxy-4,5-dihydroisoxazole 
• 24583-70-8 (E)-3-(p-chlorophenyl)prop-2-en-1-ol 

Downstream Products

• 1093649-70-7 3-(N,N-diisopropylamino)benzonitrile 
• 623-03-0 4-Cyanochlorobenzene 
• 934-87-2 S-phenyl thioacetate 
• 1258507-04-8 (Z)-S-phenyl 3-amino-3-(4-chlorophenyl)prop-2-enethioate 
• 14688-31-4 3-(4′-chlorophenyl)-5-(4′′-methylphenyl)isoxazole 
• 1048922-51-5 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid 
• 81963-65-7 2-(3-(4-chlorophenyl)isoxazol-5-yl)-1-phenylethan-1-one 

Relevant academic research and scientific papers

Rhodium(iii)-catalysed decarboxylative C-H functionalization of isoxazoles with alkenes and sulfoxonium ylides

Decarboxylative C-H functionalization of isoxazoles with electron-deficient alkenes and sulfoxonium ylides at the C5 position was achieved in the presence of rhodium(iii) catalysts to give the corresponding alkenylation and acylmethylation products, respe

Preparation method of isoxazole derivative

The invention relates to a preparation method of an isoxazole derivative, which comprises the following steps of mixing an propargyl alcohol derivative, a halogen source, an acid and a solvent, and heating to react; adding the hydroxylamine into the react

Rhodium(iii)-catalysed carboxylate-directed C-H functionalizations of isoxazoles with alkynes

An efficient oxidative [4+2] annulation of isoxazolyl-4-carboxylic acids with internal alkynes proceeded in the presence of the [Cp?RhCl2]2 catalyst. Oxidants controlled the formation of pyranoisoxazolones and isoquinolines. A decarb

Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position

A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.

Reactions of trans-1-(β-aroylvinyl)pyridinium bromides with hydroxylamine hydrochloride

Reactions of trans-1-(β-aroylvinyl)pyridinium bromides with hydroxylamine hydrochloride lead to a mixture of substituted isoxazoles regardless of the substituent nature in the aromatic core and the solvent.

Polymer-supported vinyl sulfone as an efficient reagent for the synthesis of 3-monosubstituted isoxazoles

Polystyrene-supported vinyl sulfone reagent has been developed and used for solid-phase organic synthesis of 3-monosubstituted isoxazoles by 1,3-dipolar cycloaddition reaction with nitrile oxides and subsequent cleavage from the polymer support through an

A novel synthesis of N-unsubstituted β-enamino thioesters from 3-arylisoxazoles and 3-aryl-5-phenylthio-2-isoxazolines

A novel procedure for the synthesis of N-unsubstituted β-enamino thioesters, (Z)-S-phenyl 3-amino-3-arylprop-2-enethioates, from 3-arylisoxazoles or 3-aryl-5-phenylthio-2-isoxazolines is described and a plausible mechanism for the reaction is proposed. Some examples of conversion of one β-enamino thioester [(Z)-S-phenyl 3-amino-3-phenylprop-2-enethioate] into N-unsubstituted β-enaminoacyl derivatives (β-enamino esters, β-enamino amides, and β-keto amides) are also reported. Georg Thieme Verlag Stuttgart - New York.

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA

3-Arylisoxazoles react with LDA in THF at 0 °C affording syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones (bis-azetidinones), via stereoselective dimerization of an azetinone anion intermediate. A?fragmentation reaction affording arylnitriles may compete with electronic and steric effects of the substituent present in the aryl group being pivotal in determining the outcome of this reaction. An interesting behaviour with LDA of arylnitriles arising from the fragmentation reaction of some 3-arylisoxazoles was also observed. N,N-Diisopropylaminobenzonitriles were in fact formed (plausibly via a benzyne mechanism) from 3-(4-chlorophenyl)isoxazole and 3-(2-chlorophenyl)isoxazole, whereas 3-(2-methylphenyl)isoquinolin-1-amine was isolated starting from 3-(2-methylphenyl)isoxazole and LDA.

Synthesis of azirines containing aldehyde functionality and their utilization as synthetic tools for five membered oxazoles and isoxazoles

(Chemical Equation Presented) A simple and useful procedure for the synthesis of azirines containing aldehyde functionality from open chain bromo/chloro-aldehydes at room temperature is reported. The scope of the ring expansion reaction of a number of 3-s