117312-00-2Relevant academic research and scientific papers
A simple synthesis of 2-deoxy-3-thioinosine and its phosphorothioamidite
Luo, Qianfu,Cheng, Renjun,Wang, Qiu,Bao, Shuming
, p. 106 - 110 (2013)
5-O-{[Bis(4-methoxyphenyl)(phenyl)methyl])-2-deoxy-3-thioinosine and its S-phosphorothioamidite were prepared in five and six steps, respectively, from commercially available 2-deoxyinosine. The key 3-thio intermediate was synthesized by two sequential configuration inversions: a one-pot oxidation/reduction reaction and an S reaction. This intermediate was readily converted into the target compound with a high yield. Compared with other methods, this synthetic strategy has the advantages of brief reaction steps, a relatively high overall yield, and regioselectivity for the configuration inversions. The products might be useful as intermediates for the preparation of new functionalized nucleosides. Georg Thieme Verlag Stuttgart · New York.
