1173155-32-2Relevant academic research and scientific papers
Tetrahydrocarboline analogs as MCH-1 antagonists
Henderson, Alan J.,Deering, Dustin,Grabowski, James F.,Hadden, Mark,Jiang, Xiaowu,Khmelnitsky, Yuri,Luche, Michele,Surman, Matthew D.,Cheetham, Sharon,Vickers, Steven,Viggers, Jean,Guzzo, Peter R.
scheme or table, p. 7024 - 7028 (2011/01/05)
A new series of tetrahydrocarbolines with potent MCH-1 antagonist activity were synthesized, using a conformationally constrained design approach towards optimizing pharmacokinetic properties. Two compounds from this series were progressed to a 5-day diet-induced obesity mouse screening model to evaluate their potential as weight loss agents. Both compounds produced a highly significant reduction in weight, which was attributed to their improved pharmacokinetic profile.
(1-AZINONE) -SUBSTITUTED PYRIDOINDOLES AS MCH ANTAGONISTS
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Page/Page column 44, (2009/09/04)
Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are
