1173181-30-0

Upstream product

• 88980-13-6 (S)-hept-6-en-2-ol 
• 392250-82-7 (S)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxybenzyloxy)-propan-1-ol 
• 392250-83-8 (S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-propionaldehyde 
• 142561-88-4 (S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol 
• 1372785-58-4 ((3S,4S)-4-(benzyloxy)-3-(4-methoxybenzyloxy)oct-7-enyloxy)(tert-butyl)diphenylsilane 
• 1372785-57-3 (3S,4S)-1-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)oct-7-en-4-ol 
• 1372785-56-2 tert-butyl ((S)-3-(4-methoxybenzyloxy)-3-((S)-oxiran-2-yl)propoxy)diphenylsilane 
• 1372785-55-1 (2S,3S)-5-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-(4-methoxybenzyloxy)pentyl 4-methylbenzenesulfonate 
• 1372785-62-0 (2R,5S,6S)-5-(benzyloxy)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-tetrahydro-2H-pyran-2-carbaldehyde 
• 1372785-54-0 (2S,3S)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)pentane-1,2-diol 
• 1384898-59-2 C₃₈H₄₆O₅Si 
• 1372785-53-9 tert-butyl ((S)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxybenzyloxy)propoxy)diphenylsilane 
• 1372785-52-8 (S)-4-((S)-1-(4-methoxybenzyloxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolane 
• 1372785-49-3 2-((2S,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)acetic acid 

Relevant academic research and scientific papers

Formal total synthesis of aspergillides A and B

The formal total synthesis of the cytotoxic 14-membered macrolides, aspergillides A and B is described. A combination of a chiron approach and an asymmetric synthesis is adopted for the synthesis of the target macrolides. The required 2,6-syn and 2,6-anti

Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B

Total, stereoselective syntheses of the naturally occurring, cytotoxic macrolides aspergillide A and B are described. Olefin metatheses and asymmetric allylations were key steps in the synthetic sequences. Cytotoxicity assays against several tumor cell li

Stereoselective synthesis of the cytotoxic macrolide aspergillide B

A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by m