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Relevant academic research and scientific papers

BF3/nano-sawdust as a green, biodegradable and inexpensive catalyst for the synthesis of highly substituted dihydro-2-oxopyrroles

BF3/nano-sawdust was used as a readily available, inexpensive, biodegradable and environmentally benign heterogeneous solid acid catalyst for the one-pot cascade synthesis of highly functionalized dihydro-2-oxypyrroles. Four-component reactions (4CRs) of dialkylacetylenedicarboxylates, primary amines and aldehydes were used for the synthesis of these compounds under thermal conditions.

Maltose, a natural, efficient and economical catalyst for the one-pot synthesis of highly substituted dihydropyrrol-2-ones

Maltose is a natural, economical and very effective catalyst for promotion of the four-component domino reaction between amines, dialkyl acetylenedicarboxylates and formaldehyde to afford substituted dihydropyrrol-2-ones at room temperature. The advantages of this protocol are good yields, short reaction times, low cost, environmentally friendly, simple work-up and lack of need for column chromatography. Website

Caffeine as a naturally green and biodegradable catalyst promoted convenient and expedient synthetic route for the synthesis of polysubstituted dihydro-2-oxypyrroles

A green, convenient, high yielding and one-pot procedure for synthesis of high substituted dihydro-2-oxypyrroles by domino four-component condensation reaction between aromatic/aliphatic amines, dialkyl acetylenedicarboxylate and formaldehyde in the presence of a catalytic amount of caffeine as a green, natural, expedient and biodegradable catalyst under ambient temperature was studied. The salient features of this green approach are simplicity of operation and work-up procedures with no necessity of chromatographic purification steps, use of safe, non-volatile, non-corrosive and green catalyst, the availability and easy to handle of this solid catalyst, one-pot reaction, economical and clean synthesis.

Nano-TiCl4/SiO2: An efficient catalyst for the one-pot synthesis of highly substituted dihydro-2-oxopyrroles

Nano-TiCl4/SiO2 was used as a readily available, inexpensive, efficient, and environmentally benign heterogeneous solid acid catalyst for the one-pot cascade synthesis of highly functionalized dihydro-2-oxopyrroles. Four-component reaction (4CR) of dialkyl acetylenedicarboxylates, aniline derivatives, and formaldehyde was employed for the synthesis of these compounds under thermal conditions. Graphical abstract: [Figure not available: see fulltext.].

An efficient one-pot access to substituted dihydropyrrol-2-one derivatives using sucrose as natural, biodegradable and inexpensive catalyst

An efficient and simple procedure for the synthesis of highly substituted dihydropyrrol-2-ones has been developed via one-pot four-component condensation of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of sucrose as an organocatalyst. The salient advantages of this method are using a natural, biodegradable and commercial available catalyst, good yields, short reaction times, simple work-up and lack of need for column chromatography. An efficient and simple procedure for the synthesis of highly substituted dihydropyrrol-2-ones has been developed via one-pot four-component condensation of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of sucrose as an organocatalyst. The salient advantages of this method are using a natural, biodegradable and commercial available catalyst, good yields, short reaction times, simple work-up and lack of need for column chromatography. Copyright

Imin-based synthesis of polyfunctionalized dihydro-2-oxypyrroles catalyzed by glycine amino acid via tandem Michael–Mannich cyclocondensation reaction under ambient temperature

An efficient and mild synthetic route to the convenient one-pot preparation of polyfunctionalized dihydro-2-oxypyrroles has been developed and catalyzed via glycine amino acid as a natural bio-based and biodegradable catalyst using imin-based four condensation domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde via tandem Michael–Mannich cyclocondensation reaction under ambient temperature. The reactions complete in less time, but the products are obtained in outstanding yields. This environmentally friendly method includes the noticeable properties such as bio-based and green catalyst, direct workup without column chromatographic separation, cost-effective, mild and simple synthesis, one-pot procedure and high atom economy.

Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles

A highly versatile and convenient synthetic route for biologically active α-amino acid, glutamic acid catalyzed facile and mild preparation of polyfunctionalized dihydro-2-oxypyrroles via one-pot, four condensation domino reaction between aromatic/aliphatic amines, dialkyl acetylenedicarboxylates and formaldehyde have been studied. The route includes green, biodegradable and inexpensive α-amino acid catalyst, high atom-economy, simplicity of operation and work-up procedures, without chromatographic purification steps. The solid catalyst, non-toxic or hazardous, easily handled with mild reaction conditions and excellent yields are the notable benefits of the highly efficient and expedient synthesis of these products.

Trifluoroacetic acid catalyzed one-pot four-component domino reaction for the synthesis of substituted dihydro 2-oxypyrroles

Trifluoroacetic acid was applied as an effcient catalyst for the one-pot four-component synthesis of N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via the domino reaction of amines, formaldehyde and dialkyl acetylenedicarboxylates at ambient temp

Phthalic acid: A green, biodegradable and environmentally benign nature difunctional Br?nsted acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and substituted dihydro-2-oxypyrroles

Phthalic acid as a green, biodegradable economical and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives via β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions and one-pot four-component domino condensation of substituted dihydro-2-oxypyrrole by reaction of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with short reaction times and excellent yields is reported. The most benefits this procedure are such as green, biodegradable, inexpensive and non-toxic catalyst, eco-friendly, high catalytic activity, efficient, easily separation with no column chromatographic separation, simple operational procedures, one-pot, excellent yields, environmentally benign nature.

Pectin; hetero polysaccharide as a green and natural catalyst for the synthesis of dihydro-2-oxopyrroles and 3,4,5-trisubstituted furan-2(5H)-ones

Use of green and biodegradable catalyst in organic synthesis is undeniable. Easy access, inexpensive, natural and green catalysts are valuable. In this study, a green procedure by using pectin as a green and natural catalyst for the one-pot synthesis of dihydro-2-oxopyrroles and 3,4,5-trisubstituted furan-2(5H)-ones at ambient temperature in aqueous media has been developed. This methodology has some advantages such as: use of a hetero polysaccharide as a easy access and biodegradable catalyst, clean work-up and no need to column chromatography.