An efficient one-pot access to substituted dihydropyrrol-2-one derivatives using sucrose as natural, biodegradable and inexpensive catalyst

Article abstract of DOI:10.1002/jccs.201300311

An efficient and simple procedure for the synthesis of highly substituted dihydropyrrol-2-ones has been developed via one-pot four-component condensation of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of sucrose as an organocatalyst. The salient advantages of this method are using a natural, biodegradable and commercial available catalyst, good yields, short reaction times, simple work-up and lack of need for column chromatography. An efficient and simple procedure for the synthesis of highly substituted dihydropyrrol-2-ones has been developed via one-pot four-component condensation of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of sucrose as an organocatalyst. The salient advantages of this method are using a natural, biodegradable and commercial available catalyst, good yields, short reaction times, simple work-up and lack of need for column chromatography. Copyright