1173282-71-7

Upstream product

• 120-72-9 indole 
• 66616-72-6 5-phenyl-1H-indole 
• 100-52-7 benzaldehyde 
• 100-61-8 N-methylaniline 

Relevant academic research and scientific papers

[HMim] BF in water4 Ionic liquid catalytic synthesis of 3 - amine alkyl indole (by machine translation)

The invention relates to a method for synthesizing an organic synthetic intermediate 3-amino-alkylindole. The [HMim] BF4 ionic liquid serves as a catalyst, and the 3-amino-alkylindole is synthesized from aromatic aldehyde, indole and secondary amine in water by virtue of a one-pot process. The method disclosed by the invention has the advantages that the catalyst is safe, readily available and environment-friendly and can be recycled, the reaction conditions are mild, the operation is simple and convenient, the yield is high and the like.

Monolaurate catalytic preparation of 3 - amine alkyl indole

The invention relates to a preparation method of organically synthesized midbody 3-amino alkyl indole. According to the preparation method, lauric acid is directly used as a catalyst, and the 3-amino alkyl indole is prepared by aromatic aldehyde, indole and secondary amine through a single-step method. The preparation method has the characteristics of being free of catalyst preparation, safe, low in cost, mild in reaction condition, simple to operate, free of organic solvent in the reaction process and relatively high in productivity.

Iron mediated one pot three component synthesis of 3-substituted indoles via aerobic iminium ion formation

An efficient and economical method was developed for the synthesis of 3 substituted indoles by a highly efficient one-pot three component coupling reaction of substituted or unsubstituted benzyl alcohol, N-methyl aniline or pyrrolidine, and indoles or sub

Catalyst-free, ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction Dedicated to Professor Richard A. Gibbs (1962-2014)

A highly efficient and sustainable approach for the multi-component synthesis of biologically important 3-amino alkylated indoles has been investigated via Mannich-type reaction under catalyst-free, ethylene glycol as a recyclable promoting medium. The wide applicability of the present method was examined with various substrates viz substituted aldehydes, indoles and secondary amines. This method will be useful for a large scale synthesis of 3-amino alkylated indoles without the use of column chromatography. The present method provides higher environmental compatibility and sustainability factors such as smaller E-factor (0.433) and higher atom-economy (AE = 93.3%).

One-pot synthesis of 3-[(N-alkylanilino)(aryl)methyl]indoles via a transition metal assisted three-component condensation at room temperature

A simple and highly efficient protocol for the one-pot synthesis of a series of 3-[(N-alkylanilino)(aryl)methyl]indoles has been developed based on low-cost and environmentally benign zirconium oxychloride octahydrate and copper chloride dihydrate catalysts via three-component condensation between indoles, aromatic aldehydes, and N-alkylanilines at room temperature under neat condition. Mild reaction conditions, operational simplicity, high atom-economy, good yields in relatively shorter reaction times, use of low-cost and eco-friendly catalysts are some of the salient features of this protocol. A simple and highly efficient protocol for the one-pot synthesis of a series of 3-[(N-alkylanilino)(aryl)methyl]indoles has been developed based on low-cost and environmentally benign zirconium oxychloride octahydrate and copper chloride dihydrate catalysts via three-component condensation between indoles, aromatic aldehydes, and N-alkylanilines at room temperature under neat condition. Mild reaction conditions, operational simplicity, high atom-economy, good yields in relatively shorter reaction times, and use of low-cost and eco-friendly catalysts are the key advantages of the present protocol.

Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water

An efficient micelle promoted one-pot synthesis of 3-amino alkylated indoles has been developed via a three-component Mannich-type reaction from secondary amines, aldehydes and indoles in water under mild reaction conditions. In this Mannich-type reaction

CelluloseSulfonic acid: An efficient, recyclable, and biodegradable solid acid catalyst for the synthesis of 3-aminoalkylindoles

Three-component coupling (3CC) of indoles, aldehydes, and N-alkylanilines has been accomplished using a catalytic amount of cellulosesulfonic acid under mild reaction conditions to furnish the 3-aminoalkylindoles at room temperature in short reaction times and in relatively good to excellent yields and selectivity. The use of biodegradable cellulosesulfonic acid makes this method quite simple, convenient, and economically viable for the synthesis of 3-aminoalkylindoles.

A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3-chlorophenylboronic acid as a catalyst under ambient temperature conditions. The three-component reaction of indoles, aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields. This protocol presents some remarkable features such as mild reaction conditions, simple workup procedure and excellent yields.

One-pot synthesis of 3-substituted indole derivatives using moisture stable, reusable, and task specific ionic liquid catalysts

Moisture stable Broensted acidic (BIL) and Lewis acidic ionic liquid catalysts have been synthesized and their catalytic activities have been examined in the synthesis of biologically important indole-3-derivatives. Catalytic activities of these ionic liquid catalysts have been investigated for some important catalytic reactions such as three component coupling reaction of benzaldehyde, N-methylaniline and indole and Michael addition reaction of indole with β- nitrostyrene/chalcone/acetyl acetone. In all these reactions, BIL functionalized with sulfonic acid is found to be the best task specific catalyst. BILs are inexpensive and easy to synthesize, and can be separated easily and reused for three cycles without significant loss in catalytic activity. Catalyst offers several attractive features such as low cost, high catalytic activity/selectivity and recyclability.

PANI-HBF4: A reusable polymer-based solid acid catalyst for three-component, one-pot synthesis of 3-substituted amino methyl indoles under solvent-free conditions

A simple, fast, efficient, high-yielding, and green process is developed for one-pot, three-component synthesis of 3-substituted amino methyl indoles under solvent-free conditions using polyaniline salt as polymer-based reusable solid acid catalyst at room temperature. The advantages of polyaniline salt catalyst are ease of synthesis and handling, low cost, versatality, and recyclability. Copyright Taylor & Francis Group, LLC.