1173290-17-9Relevant academic research and scientific papers
New antiprotozoal agents: Their synthesis and biological evaluations
Upadhayaya, Ram Shankar,Dixit, Shailesh S.,F?ldesi, Andras,Chattopadhyaya, Jyoti
supporting information, p. 2750 - 2758 (2013/07/05)
Here we report identification of new lead compounds based on quinoline and indenoquinolines with variable side chains as antiprotozoal agents. Quinolines 32, 36 and 37 (Table 1) and indenoquinoline derivatives 14 and 23 (Table 2) inhibit the in vitro growth of the Trypanosoma cruzi, Trypanosoma brucei, Trypanosoma brucei rhodesiense subspecies and Leishmania infantum with IC 50 = 0.25 μM. These five compounds have superior activity to that of the front-line drugs such as benznidazole, nifurtimox and comparable to amphotericin B. Thus these compounds constitute new 'leads' for further structure-activity studies as potential active antiprotozoal agents.
