117346-07-3Relevant articles and documents
Synthesis of novel isoindolone-based medium-sized macromolecules and triazole containing heterocyclic compounds
Boddu, Lingaiah,Potlapati, Varakumar,Subhashini
, p. 3197 - 3205 (2019)
A series of novel isoindolone-based macromolecules of medium-sized heterocyclic rings, such as 7,8-dihydro-6H-benzo[4,5][1,6,3]dioxazonino[2,3-a]isoindol-14(9aH)-one derivatives (5a-l), were synthesized and its frame work incorporating with a triazole moiety on phenol, ie, 2-(4-((1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)isoindoline-1,3-dione (9a-f) and also a triazole moiety on carboxylic acid, ie, (1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl 4-(1,3-dioxoisoindolin-2-yl)benzoate derivatives (13a-e) with various substitutions on aryl ring system have synthesized. All the synthesized compounds were characterized and confirmed with IR, 1H NMR, 13C NMR, and ESI mass spectral analysis.
Synthesis method of pyrrotinib intermediate
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Paragraph 0016-0021, (2020/02/14)
The invention discloses a synthesis method of a pyrrotinib intermediate. According to the method, 2-fluoro-5-nitrophenol and phthalimide are reacted in an aqueous solution in the presence of an acid-binding agent to generate N-(2-hydroxy-4-nitrophenyl) phthalimide. The synthesis method provided by the invention is simple in post-treatment, high in product purity, high in yield, environment-friendly and suitable for industrial production.
Acrylamide derivative and preparation method and application thereof
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Paragraph 0043; 0044; 0045, (2019/06/30)
The invention provides an acrylamide derivative and a preparation method and application thereof. The acrylamide derivative is represented by general formula shown in the description, wherein R is oneof-H,-OH or-COOH, and R1 is one of-H,2-OH or 3-OH.The acrylamide derivative has the beneficial effects that the phthalimide substituted acrylamide derivative is used as a comonomer of an acrylic copolymer andprevents the corrosion resistance of the acrylic copolymer to chemicalprints; meanwhile the acrylamide derivative improves the sensitivity, the wear resistance and the development adaptability of a lithographic plate material.