1173634-67-7Relevant articles and documents
Synthesis and antimicrobial activity of novel pyrazole derivatives
Al-Ghamdi, Hassan Mohammed
, p. 391 - 398 (2019)
This work aimed to synthesis some new different heterocyclic compounds based on phenylpyrazole-4-carbaldehyde derivative (1) reacted with cyanoacetohydrazide to afford N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]-2-cyanoacetohydrazide (2). I
Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives
Khidre, Rizk E.,Abu-Hashem, Ameen A.,El-Shazly, Mohamed
experimental part, p. 5057 - 5064 (2011/11/29)
A new series of 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3- carbonitrile such as hydrazide hydrazones 3a-h; ethane-1,2-diaminopyridine 6; phthalimidopyridines 8a,b; hydrazides 10a,b; urea 11a and thiourea 11b were synthesized in a good to excellent yield in step efficient process, using 1-amino-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1) as a key intermediate. The antibacterial and antifungal activities of the synthesized compounds were evaluated. The obtained data indicated that the majority of the tested compounds exhibited both antibacterial and antifungal activities, particularly compounds 8a and 8b showed a comparable effect to a well known antibacterial and antifungal agents.
