1562-12-5

Basic information

• Product Name: 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE
• Synonyms: 1-amino-2-keto-4,6-dimethyl-nicotinonitrile;1-Amino-3-cyano-4,6-dimethylpyridine-2-one;1-amino-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile;1-amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile;1-amino-4,6-dimethyl-2-oxopyridine-3-carbonitrile;1-Amino-3-cyano-4,6-dimethylpyridin-2-one98%
• CAS NO: 1562-12-5
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.1804
• Mol File: 1562-12-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 174 °C(Solv: ethanol (64-17-5))
• Boiling Point: 282.5°Cat760mmHg
• Flash Point: 124.7°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 0.00333mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• PKA: -0.58±0.70(Predicted)
• CAS DataBase Reference: 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE(1562-12-5)
• EPA Substance Registry System: 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE(1562-12-5)

Safety Data

• Hazardous Substances Data: 1562-12-5(Hazardous Substances Data)

Usage

General Description

1-Amino-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is a chemical compound with the molecular formula C8H10N4O. It is a heterocyclic compound with a pyridine ring, and contains an amino group, two methyl groups, and a carbonyl group. This chemical is commonly used as a building block in organic synthesis, and has applications in pharmaceutical and agrochemical industries. It is also a potential intermediate in the synthesis of various biologically active compounds. Due to its versatile reactivity and potential biological activity, 1-amino-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is a valuable compound in the field of chemical research and development.

InChI:InChI=1/C8H9N3O/c1-5-3-6(2)11(10)8(12)7(5)4-9/h3H,10H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 140-87-4 Cyanoacetohydrazide 
• 109-89-7 diethylamine 
• 123-54-6 acetylacetone 
• 1218950-87-8 1,1'-{piperazine-1,4-diylbis[(Z)-methylylidenenitrilo]} bis(4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile) 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Downstream Products

• 1343478-50-1 3-amino-N-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-4-(4-methoxyphenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxamide 
• 1173555-66-2 1-[(3-benzofuran-2-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-amino]-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1343478-46-5 (Z)-1-(2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-ylamino)-1-phenylvinylamino)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 709015-82-7 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylurea 
• 328026-06-8 1-[(4-fluoro-benzylidene)-amino]-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1173634-67-7 1?(((5?chloro?3?methyl?1?phenyl?1H?pyrazol?4?yl)methylene)amino)?4,6?dimethyl?2?oxo?1,2?dihydropyridine?3?carbonitrile 
• 1343478-47-6 1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 198067-95-7 4,6-dimethyl-2-oxo-1-[(thiophen-2-ylmethylene)-amino]-1,2-dihydro-pyridine-3-carbonitrile 
• 101435-36-3 1-(4-methoxy-benzylidenamino)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid amide 
• 100868-00-6 4,6-dimethyl-1-(4-nitro-benzylidenamino)-1H-pyridin-2-one 
• 101091-54-7 1-benzylidenamino-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid amide 
• 16115-08-5 6-Hydroxy-2,4-lutidin 
• 183473-54-3 1-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 89814-99-3 4,6-Dimethyl-2-oxo-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1,2-dihydro-pyridine-3-carbonitrile 

Relevant articles and documents

Gas-phase pyrolysis in organic synthesis: A route for synthesis of cyanamides

(Chemical Equation Presented) Pyrolysis of 1,7-di-[(E)-1- morpholinomethylidene]- and 1,7-di-[(E)-1-piperidino-methylidene]-4,6,10,12- tetramethylamino-2,8-dioxo-1,7-diaza-3,5,9,11-cyclododecatetraene-3, 9-dicarbonitrile 6a,b afforded pyridone 10 in addition to cyanamides 11a,b. On the other hand, pyrolysis of 1-[E-(4-(E-3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)- ylimino) methylpiperazin-1-yl] methylenamino-4,6-dimethyl-2-oxo-1,2- dihydropyridine-3-carbonitrile 8 gave 1-amino-4,6-dimethyl-2-oxo-1,2- dihydropyridine-3-carbonitrile 13 as well as piperazine. The mechanism of pyrolysis and the effect of stereochemistry of pyrolyzed substrates on the nature of the pyrolysates are discussed.

Pyrolysis of amino nitriles, cyanohydrazones, and cyanoacetamides. Part I. Elimination reaction of 1-arylmethyleneamino-1,2-dihydro-4, 6-dimethyl-2-oxopyridine-3-carbonitriles and substituted benzaldehyde cyanoacetylhydrazones

Pyrolysis of the Schiff bases of 1-arylmethyleneamino-1,2-dihydro-4, 6-dimethyl-2-oxopyridine-3-carbonitriles (1-5) has been studied. These compounds eliminate via a six-membered transition state to produce substituted benzonitriles and 2-hydroxy-4,6-dimethylpyridine-3-carbonitrile. These eliminations are unimolecular first-order reactions. The kinetic data gave a good correlation with σ0 values of the substituents on the aryl group with ρ = 0.83 at 520 K. Utilization of the pyrolytic reaction in synthesis of various benzonitriles is considered, and mechanistic information has been obtained by comparing the kinetic data and product analysis of the Schiff bases with their open-chain substituted benzaldehyde cyanoacetylhydrazones (6-9) analogues.

Novel Pyrethroid Insecticides. III. Synthesis of Some N-(1-Pyridyl) Substituted Amides of Cyclopropanecarboxylic Acids

New type pyrethroid amides have been synthesized starting from the corresponding cyclopropanecarboxylic acid chlorides and N-amino-2-pyridone derivatives.