117365-69-2Relevant academic research and scientific papers
Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: An organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach
Chen, Xiaofei,Xiong, Fangjun,Chen, Wenxue,He, Qiuqin,Chen, Fener
, p. 2723 - 2728 (2014/04/17)
An efficient asymmetric synthesis of atorvastatin calcium has been achieved from commercially available diethyl 3-hydroxyglutarate through a novel approach that involves an organocatalytic enantioselective cyclic anhydride desymmetrization to establish C(
CHEMOENZYMATIC SYNTHESIS OF A C5-CHIRAL BUILDING BLOCK: A SUBSTRATE MODIFICATION APPROACH.
Roy, Rene,Rey, Allan, W.
, p. 4935 - 4938 (2007/10/02)
The enantioselectivity of α-chymotrypsin hydrolysis of prochiral dimethyl-3-hydroxyglutarates was contrilled by the proper choice of the hydroxyl protecting groups.This strategy allows the synthesis of a versatile C5-chiral building block.
