117375-28-7

Upstream product

• 485-72-3 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on 
• 1157-39-7 7-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 486-66-8 daidzein 

Downstream Products

• 37816-21-0 4′,7,8-trimethoxyisoflavone 
• 75187-63-2 8-hydroxydaidzein 
• 1307770-17-7 6-(4-methoxyphenyl)-7-(2-hydroxy-3-bromo-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

Synthetic method of polyhydroxy isoflavone

The invention discloses a synthetic method of polyhydroxy isoflavone. The method comprises the following steps: (1) reacting 4', 7-dimethoxyisoflavone with N-bromosuccinimide, and controlling the molar ratio of 4', 7-dimethoxyisoflavone to N-bromosuccinimide and a reaction temperature to enable one or two hydrogen atoms on a 4', 7-dimethoxyisoflavone carbon ring to be substituted by bromine atomsto generate corresponding bromide; (2), enabling the bromide in the (2) to react with sodium methoxide under the action of cuprous salt to enable bromine atoms on a carbon ring of the bromide to be substituted by methoxy to obtain a methoxylation product; and (3), carrying out a demethylation reaction on the methoxylation product obtained in the (3) under the action of aluminum chloride and dimethyl sulfide to obtain polyhydroxy isoflavone. The method has the advantages of abundant sources of initial raw materials, mild reaction conditions, good selectivity and high yield, and is suitable forindustrial production. The purity of the product is greater than 99.0%, and the product can be used for pharmacological activity research.