1173891-46-7

Upstream product

• 85-44-9 phthalic anhydride 
• 126-81-8 dimedone 
• 587-04-2 m-Chlorobenzaldehyde 
• 7803-57-8 hydrazine hydrate 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 

Relevant academic research and scientific papers

Nano-ferrite supported glutathione as a reusable nano-organocatalyst for the synthesis of phthalazine-trione and dione derivatives under solvent-free conditions

Nano-organocatalyzed one-pot four-component reactions for the synthesis of phthalazine-trione/dione derivatives have been devised for the first time from easily accessible starting materials under solvent-free conditions. This methodology showed very good substrate scope and high degree of tolerance for a variety of aldehydes (including aliphatic and heteroaromatic aldehydes) and active methylene compounds. Moreover, the catalyst can be easily separated from the reaction mixture because of its highly paramagnetic nature, by using an external magnet, and can be reused in five more consecutive runs without much decrease in catalytic activities. Other significant advantages of this method are shorter reaction time, good yield, simple work-up procedure, easy catalyst handling etc.

Solvent-free, sonochemical, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones catalyzed by Fe3O4@SiO2-imid-PMAn magnetic nanoparticles

A practical and green method for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones using Fe3O4@SiO2-imid-PMAn nanoparticles as an eco-friendly magnetic catalyst from the four-component condensation, solvent-free reaction of phthalic anhydride, hydrazinium hydroxide, 1,3-diketones, and aldehydes under thermal or ultrasound irradiation at room temperature is described. This new procedure has notable advantages such as operational simplicity, excellent yields, short reaction time, and absence of any tedious work-up or purification. In addition, thermal stability, easy preparation and separation of the catalyst make it a good heterogeneous system and a useful alternative to other heterogeneous catalysts. Also, the catalyst can be easily recovered by a magnetic field and reused for eight consecutive reaction cycles without significant loss of activity.

One-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones via nano γ-Al2O3/BF3/Fe3O4 as an efficient catalyst and theoretical DFT study on them

Experimental and computational studies were carried out for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones using γ-Al2O3/BF3/Fe3O4 as a nanocatalyst in optimized and solvent-free conditions. The most significant features of the existing protocol are easy preparation of the catalyst, short reaction times, environmentally benign, and milder reaction conditions. The analysis data were reported using the experimental results of this investigation, such as: H-NMR, FT-IR (Fourier-transform infrared spectroscopy), X-ray diffraction, vibrating-sample magnetometer, Thermal gravimetric analysis (TG-DTG), nitrogen adsorption isotherm, Field Emission Scanning Electron Microscopy, and Transmission electron microscopy images of nanocatalyst. In this study, 2H-indazolo[2,1-b]phthalazine-triones have also been theoretically investigated using DFT-B3LYP/6-31G method. Also, some of the physical chemistry properties have examined for conformers of products, which there was good agreement between the computational results and obtained experimental for the products.

Silica-supported tungstic acid (STA): A recyclable catalyst for the synthesis of 1H-indazolo [1,2-b]phthalazine-trione and spiro-triazolo[1,2-a]indazole-tetraone derivatives under solvent-free condition

An efficient one-pot synthesis of 1 H-indazolo[1,2-b]phthalazine-trione and spiro-triazolo[1,2-a]indazole-tetraone derivatives via three-component condensation reaction of phthalhydrazide or 4-phenylurazole, aldehydes or isatins and dimedone in the presen

Synthesis of phthalazine compounds using heterogeneous base catalyst based on silica nanoparticles obtained from rice husk

In this study, the nanoparticles of amorphous silica were easily extracted from low-cost rice husk ash. They were functionalized with 3-(chloropropyl) trimethoxysilane by incorporating chloropropyl groups directly through the condensation of nanosilica an

Preparation, characterization, and use of novel Cu@Fe3O4 MNPs in the synthesis of tetrahydrobenzimidazo[2,1-b] quinazolin-1(2 H)-ones and 2 H -indazolo[2,1- b] phthalazine-triones under solvent-free conditions

Cu@Fe3O4 MNPs as novel nanomagnetic reagents were prepared to investigate their catalytic behavior in the preparation of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones, as important biologically active compounds. Then, characteriz

Cobalt-based nanocatalyst catalyzed one-pot four-component synthesis 2H-indazolo[2,1-b]phthalazine-triones under solvent-free condition

In this research, an efficient procedure for the one-pot four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones catalyzed by a cobalt-based nanocatalyst (Co/Al2O3 nanocatalyst) is reported. The catalyst was prepared by a co-precipitation method and characterized by BET surface area, SEM, TEM, EDS and XRD analyses. A wide range of various aromatic aldehydes including electron-withdrawing and electron-releasing groups were applied and corresponding products obtained in high yields without any by-product. Moreover, the Co/Al2O3 is recyclable up to 7 consecutive runs by simple filtration.

[Bu3NH][HSO4] catalyzed: an eco-efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

A Br?nsted acidic ionic liquid [Bu3NH][HSO4] as an eco-efficient catalyst for the one-pot multicomponent synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 2H-indazolo[2,1-b]phthalazine-triones by using various aldehyde, malo

Heteropolyacid-based ionic liquid [Simp]3PW12O40 nanoparticle as a productive catalyst for the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

A novel Keggin-type heteropolyacid-based ionic liquid [Simp]3PW12O40 was developed via the reaction of the as synthesized ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 with an aq

Efficient synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives using succinimidinium N-sulfonic acid hydrogen sulfate as a new ionic liquid catalyst

Succinimidinium N-sulfonic acid hydrogen sulfate is prepared as a new ionic liquid and characterized with a variety of techniques including FT-IR, 1H and 13C NMR, SEM, mass spectra method as well as Hammett acidity function. After id