1174020-19-9

Basic information

• Product Name: 4-[({(2S,5R)-5-[(benzyloxy)amino]-piperidine-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester
• Synonyms: 4-[({(2S,5R)-5-[(benzyloxy)amino]-piperidine-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester
• CAS NO: 1174020-19-9
• Molecular Weight: 466.58
• Mol File: 1174020-19-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[({(2S,5R)-5-[(benzyloxy)amino]-piperidine-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[({(2S,5R)-5-[(benzyloxy)amino]-piperidine-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester(1174020-19-9)
• EPA Substance Registry System: 4-[({(2S,5R)-5-[(benzyloxy)amino]-piperidine-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester(1174020-19-9)

Safety Data

• Hazardous Substances Data: 1174020-19-9(Hazardous Substances Data)

Upstream product

• 120278-07-1 benzyl 4-aminopiperidine-1-carboxylate 
• 1171080-44-6 (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid benzyl ester 
• 1401540-66-6 4-[({(2S)-5-[(benzyloxy)imino]piperidin-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 1174020-21-3 4-({[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-yl]carbonyl}amino)piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLIC UREA COMPOUND

A problem to be solved by the present invention is to provide a process for producing an optically active bicyclic urea compound useful as an intermediate for β-lactamase inhibitor, in a simple and easy manner with high efficiency. The present invention includes reacting a specific ester compound with a specific amine in the presence of a metal alkoxide and/or an alkaline earth metal salt to produce the corresponding amide compound, which is then reacted with phosgene or a phosgene equivalent, followed by, if necessary, treatment with an acid or a base, to produce an optically active bicyclic urea compound. This makes it possible to produce an optically active bicyclic urea compound in a simple and easy manner with high efficiency and in high optical purity, without using expensive reagents such as catalysts and condensation agents, and without passing through protection and deprotection steps.