1171080-44-6

Basic information

• Product Name: (2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate
• Synonyms: benzyl(2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate;EOS-60409
• CAS NO: 1171080-44-6
• Molecular Formula: C₂₀H₂₄N₂O₃
• Molecular Weight: 340.41616
• Mol File: 1171080-44-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 477.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: 7.28±0.10(Predicted)
• CAS DataBase Reference: (2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate(1171080-44-6)
• EPA Substance Registry System: (2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate(1171080-44-6)

Safety Data

• Hazardous Substances Data: 1171080-44-6(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate" is a derivative of piperidine, a heterocyclic amine. It consists of a piperidine ring with a carboxylate ester group at position 2 and a benzyloxyamino group at position 5, both of which are protected by benzyl groups. (2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and bioactive compounds. Its unique structure and functional groups make it a versatile intermediate in drug discovery and medicinal chemistry research.

Upstream product

• 1416134-44-5 (x)C₂H₂O₄*C₂₀H₂₄N₂O₃ 
• 1133931-74-4 (2S)-5-(benzyloxyimino)-piperidine-2-carboxylic acid benzyl ester 
• 1171080-45-7 (2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt 
• 1416134-44-5 (2S)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt 

Downstream Products

• 1171080-45-7 (2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt 
• 1510832-19-5 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester 
• 1192651-49-2 (1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 
• 1426572-83-9 trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester 
• 1426573-07-0 (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid 
• 1174020-19-9 4-[({(2S,5R)-5-[(benzyloxy)amino]-piperidine-2-yl}carbonyl)amino]piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Convenient preparing methods for 5R-benzyloxyaminopiperidine-2S-formate and oxalate thereof

The invention relates to convenient preparing methods for 5R-benzyloxyaminopiperidine-2S-formate and oxalate thereof. L-glutamic acid is adopted as an initial raw material and esterified under the existence of an acidic agent to prepare a compound III; the compound III and 2-halogen-acetate are reacted under an alkaline condition to obtain a compound IV; the compound IV is subjected to intramolecular condensation and cyclization under functions of a strong alkali to obtain piperidin-5-one-2S-formate; the piperidin-5-one-2S-formate and benzylhydroxylamine hydrochloride are subjected to a condensation reaction under the existence of an alkali to obtain 5-benzyloxy imino piperidine-2S-formate; the 5-benzyloxy imino piperidine-2S-formate is subjected to reduction and chiral resolution to obtain the 5R-benzyloxyaminopiperidine-2S-formate oxalate; and the 5R-benzyloxyaminopiperidine-2S-formate oxalate is neutralized to obtain the 5R-benzyloxyaminopiperidine-2S-formate. The invention also provides a method for preparing avibactam. Raw materials of the methods are easily available, the methods are simple to operate, a production process is environmentally friendly, yields are high, and a production cost of the avibactam can be reduced.

SODIUM SALT OF (2S, 5R)-6-BENZYLOXY-7-OXO-1,6-DIAZA-BICYCLO [3.2.1 ] OCTANE-2-CARBOXYLIC ACID AND ITS PREPARATION

Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2- carboxylic acid and a process for its preparation is disclosed.