1174045-75-0Relevant academic research and scientific papers
Co(III)-Catalyzed Coupling-Cyclization of Aryl C-H Bonds with α-Diazoketones Involving Wolff Rearrangement
Hu, Xinwei,Chen, Xun,Shao, Youxiang,Xie, Haisheng,Deng, Yuanfu,Ke, Zhuofeng,Jiang, Huanfeng,Zeng, Wei
, p. 1308 - 1312 (2018/02/14)
An unusual cobalt(III)-catalyzed cross-coupling/cyclization of aryl C-H bonds of N-nitrosoanilines with α-diazo-β-ketoesters has been achieved. This protocol features a unique combination of Csp2-H activation/Wolff rearrangement process, allowing for the rapid assembly of quaternary 2-oxindoles. The empirical evidence and density functional theory (DFT) calculations reveal the trapping process of transient acceptor ketene intermediates by cobalt metallocycles.
ARYLATED BETA-DICARBONYL COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF
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Paragraph 0090; 0091, (2014/08/19)
The invention discloses a one pot process for the arylation of β-dicarbonyl compounds. Particularly, the present invention discloses transition-metal-free, chemo-selective, one pot process for the C-arylation of malonamide esters having Formula I at room temperature provide temperature range to obtain the arylated compounds of formula II with good yield, wherein the arylated compounds are selected from mono-arylated compound and di-arylated compound or mixture thereof.
Transition-metal-free C-arylation at room temperature by arynes
Dhokale, Ranjeet A.,Thakare, Pramod R.,Mhaske, Santosh B.
supporting information; experimental part, p. 3994 - 3997 (2012/09/21)
A facile, fluoride-induced transition-metal-free chemoselective α-arylation of β-dicarbonyl compounds (malonamide esters) at room temperature using aryne intermediates has been demonstrated. Selective mono- or diarylation and generation of a quaternary benzylic stereocenter have also been achieved. The methodology will be highly useful for the synthesis of a library of CNS depressant barbiturate drugs like Phenobarbital.
