28383-65-5

Basic information

• Product Name: α-Diazo-β-oxobenzenepropionic acid ethyl ester
• Synonyms: 2-Diazo-3-oxo-3-phenylpropanoic acid ethyl ester;2-Diazo-3-oxo-3-phenylpropionic acid ethyl ester;α-Diazo-β-oxobenzenepropanoic acid ethyl ester;α-Diazo-β-oxobenzenepropionic acid ethyl ester
• CAS NO: 28383-65-5
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 0
• Mol File: 28383-65-5.mol
• Article Data: 66

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-Diazo-β-oxobenzenepropionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-Diazo-β-oxobenzenepropionic acid ethyl ester(28383-65-5)
• EPA Substance Registry System: α-Diazo-β-oxobenzenepropionic acid ethyl ester(28383-65-5)

Safety Data

• Hazardous Substances Data: 28383-65-5(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 623-73-4 diazoacetic acid ethyl ester 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 941-55-9 4-toluenesulfonyl azide 
• 98-86-2 acetophenone 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 100-52-7 benzaldehyde 
• 2158-14-7 4-acetamidobenzenesulfonyl azide 
• 64-17-5 ethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 60317-41-1 ethyl 2-(hydroxyimino)-3-oxo-3-phenylpropanoate 
• 75-16-1 methylmagnesium bromide 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 3885-45-8 ethyl 2,3-dioxo-3-phenylpropanoate 
• 93729-29-4 ethyl 2,5-diphenyloxazole-4-carboxylate 
• 1041399-81-8 C₂₂H₂₅N₃O₅ 
• 1393641-79-6 (E)-ethyl 3-phenyl-3-((tetrahydrofuran-2-yl)oxy)acrylate 
• 1364736-15-1 4-ethyl 3-methyl 2-(dimethylamino)-5-phenylfuran-3,4-dicarboxylate 
• 216174-28-6 ethyl 2-benzoyl-3-benzoylimino-4-cyanotetrahydro-2H-pyran-2-carboxylate 
• 216174-18-4 ethyl 2-benzoyl-4-cyanotetrahydro-3-imino-2H-pyran-2-carboxylate 
• 1287721-29-2 methyl 2-{(1-ethoxy-1,3-dioxo-3-phenylpropan-2-yl)[(2,2,2-trichloroethoxy)carbonyl]amino}-3-(phenylthio)acrylate 
• 1198359-05-5 ethyl 2,3,6-triphenyl-2H-1,4-oxazine-5-carboxylate 
• 155697-64-6 ethyl 1-methyl-5-nitro-3-phenylindole-2-carboxylate 
• 27006-00-4 ethyl 5-chloro-3-phenyl-1-benzofuran-2-carboxylate 

Relevant articles and documents

Br?nsted Acid Catalyzed (4 + 2) Cyclocondensation of 3-Substituted Indoles with Donor-Acceptor Cyclopropanes

Acylcyclopropanes are employed as useful donor-acceptor cyclopropanes that undergo formal (4 + 2) cyclocondensation with N-unprotected 3-substituted indoles in the presence of a Br?nsted acid catalyst. The reaction involves the simultaneous alkylation of both the N and C-2 positions of the indole and provides access to the 8,9-dihydropyrido[1,2-a]indole scaffold that is the central core of several biologically relevant indole alkaloids in excellent yields and good selectivities.

Rhodium(III)-catalyzed C-C bond formation of quinoline N-oxides at the C-8 position under mild conditions

The Rh(III)-catalyzed C-8 selective direct alkylation and alkynylation of quinoline N-oxides has been developed. The reactions proceeded highly efficiently at room temperature over a broad range of substrates with excellent regioselectivity and functional group tolerance. This development demonstrates the synthetic utility of the N-oxide directing group as a stepping stone for remote C-H functionalization of quinolines.

A method for efficient synthesis of dinitrous compounds

The present invention discloses a method for efficiently synthesizing a diazo compound, the method of organic matter with an active methylene as a raw material,NaN3 as an auxiliary reagent for diazo transfer,CH2Cl2 as a re

Solvent-Directed Transition Metal-Free C-C Bond Cleavage by Azido-1,3,5-triazines and Their Stability-Reactivity Paradox

We report a solvent-directed and regioselective carbon-carbon bond cleavage of aryl ketones by azido-1,3,5-triazines (ATs), which is typically completed within 10 min in DMSO at room temperature, without using transition metal catalysts. The cleavage is driven by the steric hindrance in the adducts of aryl ketones and ATs, which is substantiated by DFT calculation. Our recent results showed that ATs present high reactivity in solution and high stability in solid state. This "stability-reactivity paradox"has been explained in light of the molecular and crystal structures of ATs.