1174046-75-3

Upstream product

• 1174046-74-2 3-chloro-2-((diphenylmethylene)amino)pyridin-4(1H)-one 
• 369-34-6 3,4-difluoronitrobenzene 
• 2402-77-9 2,3-dichloro-pyridine 
• 1174046-97-9 3-chloro-N-(diphenylmethylene)pyridin-2-amine 

Downstream Products

• 1174046-76-4 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)pyridin-2-amine 
• 1401415-16-4 4-(4-amino-2-fluorophenyloxy)-3-chloropyridine-2-amine 
• 1401415-20-0 4-(4-amino-2-fluorophenoxy)-N-benzhydryl-3-chloropyridin-2-amine 

Relevant academic research and scientific papers

The development of a scalable, chemoselective nitro reduction

We have demonstrated a scalable chemoselective reduction of a nitro functional group in the presence of an aryl imine using (NH4) 2S/EtOH or hydrogenation (Sponge Nickel) to afford the corresponding amino-imines in moderate to excellent yields. Other reducible groups such as aryl halides, styryl olefins, and ether linkages survived as well.

4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER

Disclosed are compounds of Formula (I)and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a