117408-99-8

Usage

Uses

Used in Pharmaceutical Development:
(S)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine is used as a pharmaceutical candidate for its potential to interact with biological targets such as receptors or enzymes, which may lead to the development of new drugs with specific therapeutic effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine serves as a subject of study for understanding its interactions with biological systems and exploring its potential as a lead compound for drug discovery.
Used in Chemical Synthesis:
(S)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine is utilized as a building block in the synthesis of more complex organic compounds, leveraging its unique structure to create molecules with novel properties and potential applications.
Used in Drug Design and Optimization:
(S)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine is employed in the design and optimization of drugs, where its chiral nature and structural features can be fine-tuned to enhance selectivity and potency towards specific therapeutic targets.

Upstream product

• 873654-36-5 (R)-(-)-2-(2-pyridinylcarboxamido)-2-phenylethan-1-ol 
• 29745-44-6 pyridine-2-carbonyl chloride 
• 98-98-6 2-Picolinic acid 
• 100-70-9 2-Cyanopyridine 
• 56613-80-0 D-2-phenylglycinol 
• 1452-77-3 pyridine-2-carboxylic acid amide 
• 19547-38-7 methyl pyridine-2-imidate 

Downstream Products

• 98-98-6 2-Picolinic acid 
• 56613-80-0 D-2-phenylglycinol 

Relevant academic research and scientific papers

Copper(II) complexes of pyridine-oxazoline (Pyox) ligands: Coordination chemistry, ligand stability, and catalysis

The coordination chemistry of copper(II) complexes bearing pyridine-oxazoline ("Pyox") ligands has been studied, with an aim of investigating their catalytic ability. Interestingly, the stability of the coordinated ligands has been shown to be much less than previously assumed: hydrolysis of the ligands by fortuitous water gives rise to 2-pyridine carboxylate formation, which encapsulate the copper in a two-dimensional coordination polymer 3. The complexes [Cu(R-Pyox)(NCMe)2(ClO4)2] {R = benzyl (Bn) 2a, phenyl (Ph) 2b, isopropyl (iPr) 2c} have been prepared, of which the benzyl derivative has been analysed by CW EPR spectroscopy. The complex [Cu(Bn-Pyox)(NCMe)2(ClO4)2] and the afore-mentioned coordination polymer have been crystallographically characterised. The performance of complexes 2a-c in the asymmetric allylic oxidation of cyclohexene is described.

Pyridine-oxazoline and quinoline-oxazoline ligated cobalt complexes: Synthesis, characterization, and 1,3-butadiene polymerization behaviors

A series of cobalt complexes supported by pyridine-oxazoline (Pyox) and quinoline-oxazoline (Quox) were synthesized. Determined by single crystal X-ray crystallography, complexes 6a and 7c adopted distorted octahedron and trigonal bipyramid geometries, re

SYNTHESIS OF OXAZOLINE COMPOUNDS

The present invention provides an improved process for preparing an oxazoline compound of the formula: (I) wherein R1 and R2 are independently hydrogen, sulfide, sulfoxide, sulfonyl, optionally substituted lower alkyl, optionally sub

Synthesis and evaluation of the in vitro DNA-binding properties of chiral cis-dichloro(pyridyloxazoline)platinum(II) complexes

A series of chiral cis-dichloro(pyridyloxazoline)platinum(II) and palladium(II) complexes were synthesized and their reactivity towards a defined sequence of single-stranded and double-stranded DNA was investigated in comparison to cisplatin. The compounds differed in the nature and absolute configuration of the substituent at the C4 position of the oxazoline ring. The DNA-binding ability of these compounds was evaluated by HPLC analysis, post metal exposure, of enzymatic digests of an undecamer duplex containing one putative metallation site. Polyacrylamide gel electrophoresis (PAGE) and thermal denaturation confirmed the results of the HPLC analysis, which showed that the stereochemistry and character of the substituent at the C4 position of the oxazoline ring had little effect on DNA binding, possibly due to the formation of monofunctional adducts.

New chiral oxazoline based-rhodium(I) catalysts: Synthesis, characterisation, heterogeneisation and applications

New chiral oxazoline-based rhodium(I) homogeneous and heterogeneous catalysts have been prepared and fully characterised through 1H and 13C NMR, CP-MAS NMR and XPS. The method used for anchoring the catalyst onto silica was found par

Asymmetric Catalysis, 45. - Enantioselective Hydrosilylation of Ketones with 2/Pyridinyloxazoline Catalysts

21 optically active 2-(2-pyridinyl)oxazolines are synthesized from 2-cyanopyridine and optically pure amino alcohols.The new pyridinyloxazolines are used as cocatalysts together with 2 as homogeneous in situ catalysts in the enantioselective hydrosilylation of prochiral ketones with diphenylsilane.After hydrolysis, 1-phenylethanol is produced in 83.4percent ee from acetophenone.Another three ketones are included into these investigations.The optical purity depends on the rhodium/ligand, rhodium/ketone, and ketone/silane ratio as well as on the solvent.Compared with other organic solvents, hydrosilylations in the solvent CCl4 without exceptions result in better chemical yields and optical purities as consequence of a change in the catalytically active species due to oxidative addition of CCl4. - Keywords: Enantioselective hydrosilylation/ Optically active secondary alcohols/ Rhodium/ pyridinyloxazoline catalysts