1174209-05-2Relevant academic research and scientific papers
Rapid access to 3-(aminomethyl)isoquinoline-fused polycyclic compounds by copper-catalyzed four-component coupling, cascade cyclization, and oxidation
Ohta, Yusuke,Kubota, Yushi,Watabe, Tsuyoshi,Chiba, Hiroaki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
, p. 6299 - 6302 (2009)
(Chemical Equation Presented) A novel copper-catalyzed synthesis of 3-(aminomethyl) isoquinoline-fused polycyclic compounds, through four-component coupling, cyclization, and oxidation, has been developed. AMannich-type reaction of 2-ethynylbenzaldehyde with paraformaldehyde and a secondary amine followed by treatment with a diamine component gave tricyclic isoquinolines through cascade cyclization and oxidation. Construction of fused isoquinolines of various ring sizes is also presented.
