1174219-85-2Relevant academic research and scientific papers
Visible light promoted photoredox C(sp3)-H bond functionalization of tetrahydroisoquinolines in flow
Filipovi?, Ana,D?ambaski, Zdravko,Vasiljevi?-Radovi?, Dana,Bond?i?, Bojan P.
, p. 2668 - 2675 (2021)
A merger of organocatalysis and visible light photoredox catalysis performed in flow allowed access to a wide range of functionalizedN-aryl-substituted tetrahydroisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. Strecker type functionaliza
Dehydrogenative C(sp3)-H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions
D?ambaski, Zdravko,Bond?i?, Bojan P.
supporting information, p. 6420 - 6425 (2019/07/09)
The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)-H bond functionalization (cross-dehydrogenative coupling) promoted by organic single electron oxidants DDQ and IBX are presented. The C-H oxidation/Mannich reaction of less reactive N-aryl substituted pyrrolidines is achieved via metal catalyzed photoredox catalysis. Operationally simple procedures provide desired products in an effective and time preserving manner.
Oxidative coupling of amines and ketones by combined vanadium- and organocatalysis
Sud, Abhishek,Sureshkumar, Devarajulu,Klussmann, Martin
supporting information; experimental part, p. 3169 - 3171 (2009/12/01)
The combination of vanadium- and organocatalysis allows for the direct oxidative coupling of cyclic tertiary amines with non-activated ketones without the need for preformed leaving groups.
