1174271-61-4Relevant academic research and scientific papers
Hydrogen bonding interactions and supramolecular networks of pyridine-aryl based thiosemicarbazides and their Zn(II) complexes
Pandurangan, Komala,Kitchen, Jonathan A.,McCabe, Thomas,Gunnlaugsson, Thorfinnur
, p. 1421 - 1431 (2013)
The synthesis of five pyridyl derived thiosemicarbazides, 1-5, is presented. All five were formed in a single step from 2-hydrazinopyridine with commercially available isothiocyanates using microwave assisted synthesis. Compounds 1-4 were structurally characterised by single crystal diffraction analysis, and showed extended supramolecular hydrogen bonding arrays. Furthermore, the Zn(ii) complexes 6 and 7 have been prepared using ligands 1 and 5, and structurally characterised, again showing elegant assemblies of metal-supramolecular structures with solvent accessible channels, demonstrating that these building units are excellent candidates for use in supramolecular chemistry and crystal engineering.
Synthesis of fused 3-amino-1,2,4-triazoles via sequential addition of aryl hydrazines to isothiocyanates and I2-mediated cyclodesulfurization
Jiao, Shufeng,Wang, Zhen,Zhao, Qiongli,Yu, Wenquan,Chang, Junbiao
supporting information, p. 3069 - 3073 (2018/05/23)
A variety of fused 3-amino-1,2,4-triazole derivatives were synthesized via addition of aryl hydrazines to isothiocyanates followed by I2-mediated oxidative cyclodesulfurization. This transition-metal-free synthetic process provides facile acces
A straightforward, one-pot protocol for the synthesis of fused 3-aminotriazoles
Comas, Horacio,Bernardinelli, Gerald,Swinnen, Dominique
supporting information; experimental part, p. 5553 - 5558 (2009/12/08)
(Chemical Equation Presented) A simple protocol for the synthesis of 3-amino-[1,2,4]triazolo[4,3-a]pyridines is reported. The newly developed one-pot methodology involves the reaction of hydrazinopyridine with isothiocyanates to give the corresponding thiosemicarbazides, which are further desulfurized in situ using polymer-supported Mukaiyama's reagent to promote the final cyclization and formation of the central core. Aryl isothiocyanates bearing both electron-donating and electron-withdrawing groups are well tolerated, and the expected compounds were obtained in excellent purities and yields after removal of salts with a SPE-NH2 column. This methodology proved to be robust in the extension to 3-amino-[1,2,4]triazolo[4,3-a]-pyrazines and 3-amino-[1,2,4]triazolo[4,3-c]-pyrimidines, and no significant differences were noticed in terms of purities and yields. The straightforward protocol developed, mix, filter, and evaporate, is appropriate for performing multiple reactions in parallel fashion without need of purification.
