1174325-88-2Relevant articles and documents
Solvent-free sonochemistry as a route to pharmaceutical co-crystals
Roy, David,James, Stuart L.,Crawford, Deborah E.
, p. 5463 - 5466 (2019)
We describe the synthesis of pharmaceutically relevant co-crystals by solvent-free sonochemistry starting from solid reagents. Employing a standard ultrasonic cleaning bath, quantitative conversions occurred within 20-60 minutes to give co-crystals of paracetamol and aspirin with a range of co-formers. As well as the utility of the method, the work raises interesting mechanistic questions regarding acoustic cavitation with no liquid phase being present.
MELOXICAM CO-CRYSTALS
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Page/Page column 30, (2020/06/01)
Co-crystals of meloxicam co-formers can be prepared by co-crystallization from a polar solvent, such as aqueous dimethyl sulfoxide; or by slurry processes, such as with ethyl acetate. Such co-crystals have improved purities and are physically stable under storage for several months.
In vivo studies of crystalline forms of meloxicam
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Page/Page column 10, (2009/08/18)
The invention is directed to novel crystalline forms of meloxicam. These novel crystalline forms of meloxicam have improved bioavailability, an enhanced rate of dissolution and shorter time to Cmax in blood, as compared to pure meloxicam.