1174325-88-2Relevant articles and documents
Solvent-free sonochemistry as a route to pharmaceutical co-crystals
Roy, David,James, Stuart L.,Crawford, Deborah E.
, p. 5463 - 5466 (2019)
We describe the synthesis of pharmaceutically relevant co-crystals by solvent-free sonochemistry starting from solid reagents. Employing a standard ultrasonic cleaning bath, quantitative conversions occurred within 20-60 minutes to give co-crystals of paracetamol and aspirin with a range of co-formers. As well as the utility of the method, the work raises interesting mechanistic questions regarding acoustic cavitation with no liquid phase being present.
In vivo studies of crystalline forms of meloxicam
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Page/Page column 10, (2009/08/18)
The invention is directed to novel crystalline forms of meloxicam. These novel crystalline forms of meloxicam have improved bioavailability, an enhanced rate of dissolution and shorter time to Cmax in blood, as compared to pure meloxicam.