1174340-52-3Relevant academic research and scientific papers
Concentration Effect in the Asymmetric Michael Addition of Acetone to β-Nitrostyrenes Catalyzed by Primary Amine Thioureas
Günler, Z. Inci,Alfonso, Ignacio,Jimeno, Ciril,Pericàs, Miquel A.
, p. 319 - 325 (2016/12/24)
Bifunctional primary amine thiourea (PAT) organocatalysts show remarkable improvement in enantioselectivity and catalytic activity (turnover frequency) in the asymmetric Michael addition of acetone to β-nitrostyrenes upon dilution. Mechanistic investigati
Enantioselective addition of aryl ketones and acetone to nitroalkenes organocatalyzed by carbamate-monoprotected cyclohexa-1,2-diamines
Flores-Ferrndiz, Jess,Stiven, Alexander,Sotorros, Lia,Gmez-Bengoa, Enrique,Chinchilla, Rafael
, p. 970 - 979 (2015/09/01)
Enantiomerically pure carbamate-monoprotected trans-cyclohexane-1,2-diamines are used as chiral organocatalysts for the addition of aryl ketones and acetone to nitroalkenes to give enantioenriched β-substituted γ-nitroketones. The reaction was performed i
Asymmetric Michael addition of ketones to nitroolefins: Pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts
Kamal, Ahmed,Sathish, Manda,Srinivasulu, Vunnam,Chetna, Jadala,Chandra Shekar, Kunta,Nekkanti, Shalini,Tangella, Yellaiah,Shankaraiah, Nagula
, p. 8008 - 8018 (2014/12/12)
Chiral pyrrolidinyl-oxazole-carboxamides were synthesized and used as efficient new organocatalysts for the asymmetric Michael addition of ketones with nitroalkenes under solvent-free conditions. Gratifyingly, the corresponding Michael adducts were obtain
New simple primary amine-thiourea organocatalysts and their application in asymmetric conjugate addition
Yu, Lu,Li, Pengfei
supporting information, p. 3697 - 3700 (2014/06/23)
A kind of simple primary amine-thiourea organocatalysts was developed. And their application in asymmetric conjugate addition of ketone to nitroalkene was investigated. In the presence of the new primary amine-thiourea, the conjugate addition of ketone to
Modular bifunctional chiral thioureas as versatile organocatalysts for highly enantioselective aza-Henry reaction and michael addition
Li, Hua,Zhang, Xu,Shi, Xin,Ji, Nan,He, Wei,Zhang, Shengyong,Zhang, Bangle
, p. 2264 - 2274 (2012/11/06)
A series of new modular bifunctional chiral thiourea organocatalysts were synthesized from natural Cinchona alkaloids and amino acids, and their performance in the aza-Henry reaction of nitroalkanes to imines, the Michael addition of acetylacetone to nitroolefins and the Michael addition of acetone to nitroolefins was investigated. Under the mild conditions, the important building blocks β-nitro amines and γ-nitro carbonyl compounds could be obtained in good yields (up to 95%) with excellent enantioselectivities (up to 99% ee) and diastereoselectivity (up to 17:1). Copyright
