1174418-54-2Relevant academic research and scientific papers
[carbonyl-11C]Benzyl acetate: Automated radiosynthesis via Pd-mediated [11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey
Lu, Shuiyu,Hong, Jinsoo,Itoh, Tetsuji,Fujita, Masahiro,Inoue, Osamu,Innis, Robert B.,Pikea, Victor W.
, p. 548 - 551 (2010)
[carbonyl-11C]Benzyl acetate ([11C]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography. [11C]1 was synthesized from [11C]carbon monoxide, iodomethane and benzyl alcohol via palladium-mediated chemistry. The radiosynthesis was automated with a modified Synthia platform controlled with in-house developed Labview software. Under production conditions, [11C]1 was obtained in 10% (n = 6) decay-corrected radiochemical yield from [11C]carbon monoxide in >96% radiochemical purity and with an average specific radioactivity of 2415 mCi/μmol. The total radiosynthesis time was about 45 min. Peak uptake of radioactivity in monkey brain (SUV = 3.1) was relatively high and may be amenable to measuring uptake and metabolism of acetate in glial cells of the brain.
