Journal of labelled compounds and radiopharmaceuticals p. 548 - 551 (2010)
Update date:2022-07-29
Topics:
Lu, Shuiyu
Hong, Jinsoo
Itoh, Tetsuji
Fujita, Masahiro
Inoue, Osamu
Innis, Robert B.
Pikea, Victor W.
[carbonyl-11C]Benzyl acetate ([11C]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography. [11C]1 was synthesized from [11C]carbon monoxide, iodomethane and benzyl alcohol via palladium-mediated chemistry. The radiosynthesis was automated with a modified Synthia platform controlled with in-house developed Labview software. Under production conditions, [11C]1 was obtained in 10% (n = 6) decay-corrected radiochemical yield from [11C]carbon monoxide in >96% radiochemical purity and with an average specific radioactivity of 2415 mCi/μmol. The total radiosynthesis time was about 45 min. Peak uptake of radioactivity in monkey brain (SUV = 3.1) was relatively high and may be amenable to measuring uptake and metabolism of acetate in glial cells of the brain.
View MoreShanghai Witshoot Internet Technology Co Ltd
Contact:+86-21-66390020
Address:Room 419, No.285 Luochuan Road (E)
Zhejiang Hoshine Silicon Industry Co., Ltd.
Contact:86-573-89179966
Address:Zhapu Town, Pinghu City, Zhejiang, China
Xi'an Unique Electronic and Chemical Co., Ltd.
Contact:+86-029-88238008
Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA
shanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Shanghai Potomer International Trade CO., LTD
Contact:+86-21-61397128
Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Doi:10.1016/j.tet.2009.04.065
(2009)Doi:10.1021/ja00231a084
(1988)Doi:10.1002/hlca.202100127
(2021)Doi:10.1039/b902018g
(2009)Doi:10.1016/j.tetlet.2009.05.105
(2009)Doi:10.1021/jm3005288
(2012)