1174495-43-2Relevant academic research and scientific papers
Work-up optimization en route to an improved process to prepare a progesterone receptor antagonist
De Koning, Pieter D.,McManus, David J.,Bandurek, George R.
experimental part, p. 1081 - 1084 (2011/12/21)
When the process to prepare nonsteroidal progesterone receptor antagonist 5 was scaled up, significant problems were encountered, and as a result lower than expected yields were obtained. In particular, the alkylation of pyrazole 2 with chloromethyl methy
Development of a Practical Synthesis of the Progesterone Receptor Antagonist 4-{[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy}-2,6- dimethylbenzo-nitrile
Bradley, Paul A.,De Koning, Pieter D.,Johnson, Patrick S.,Lecouturier, Yann C.,McManus, David J.,Robin, Aurelie,Underwood, Toby J.
experimental part, p. 848 - 853 (2010/04/22)
The development and implementation of a scaleable process for the manufacture of the nonsteroidal progesterone receptor antagonist 8 is described. Key aspects of the synthesis include (i) a telescoped chlorination- etherification sequence to prepare diket
