4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

Base Information

Chemical Name:4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate
CAS No.:1174495-43-2
Molecular Formula:C₁₈H₂₁N₃OS*H₂O₄S
Molecular Weight:425.53
Hs Code.:

Synonyms:4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

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Chemical Property of 4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

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Technology Process of 4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

There total 2 articles about 4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 4-[(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)oxy]-2,6-dimethylbenzonitrile

: 2373-51-5
chloro-methylsulfanyl-methane

: 1174495-46-5
4-({5-cyclopropyl-3-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

: 1174495-43-2
4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

Guidance literature:: 4-[(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)oxy]-2,6-dimethylbenzonitrile; chloro-methylsulfanyl-methane; With potassium tert-butylate; In 1,2-dimethoxyethane; at 20 - 30 ℃; for 9.75h; Large scale reaction;

With ammonia; In 1,2-dimethoxyethane; water; Large scale reaction;

With sulfuric acid; In Isopropyl acetate; at 20 - 25 ℃; Large scale reaction;
DOI:10.1021/op200145j

Reference yield:

: 21573-10-4
1-cyclopropyl-butane-1,3-dione

: 1174495-46-5
4-({5-cyclopropyl-3-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

: 1174495-43-2
4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide; chloro-trimethyl-silane / dichloromethane / 0 - 5 °C / Large scale reaction

1.2: Reflux; Large scale reaction

1.3: 25 °C / Large scale reaction

2.1: potassium tert-butylate / 1,2-dimethoxyethane / 9.75 h / 20 - 30 °C / Large scale reaction

2.2: Large scale reaction

2.3: 20 - 25 °C / Large scale reaction

With N-chloro-succinimide; chloro-trimethyl-silane; potassium tert-butylate; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/op200145j