1174512-20-9

Upstream product

• 258273-31-3 3-cyano-4-isopropoxybenzoic acid 
• 1174512-15-2 tert-butyl 2-(7-(N'-hydroxycarbamimidoyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 14348-41-5 3-bromo-4-hydroxy-benzoic acid 
• 16732-70-0 ethyl 5-bromoindolecarboxylate 
• 1261173-10-7 1-methylethyl 3-cyano-4-[(1-methylethyl)oxy]benzoate 
• 1174512-58-3 tert-butyl 2-(7-cyano-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1304120-32-8 tert-butyl 2-(7-cyano-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate 
• 1174512-55-0 1-oxo-2,3-dihydro-1H-pyrrolo[1,2-a]indole-7-carbonitrile 
• 1174512-53-8 7-bromo-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one 
• 1034689-05-8 1-methylethyl 3-bromo-4-[(1-methylethyl)oxy]benzoate 

Downstream Products

• 1174512-18-5 2-(7-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 

Relevant academic research and scientific papers

DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain disubstituted oxadiazole derivatives of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.