14348-41-5

Basic information

• Product Name: 3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE
• Synonyms: 3-BROMO-4-HYDROXYBENZOIC ACID;3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE;RARECHEM AL BO 0750;3-Bromo-4-Hydroxybenzoic;3-BroMo-4-hydroxybenzoic Acid
• CAS NO: 14348-41-5
• Molecular Formula: C₇H₅BrO₃
• Molecular Weight: 217.02
• EINECS: 238-299-7
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids
• Mol File: 14348-41-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 176-178°C
• Boiling Point: 338.9 °C at 760 mmHg
• Flash Point: 158.8 °C
• Appearance: white powder
• Density: 1.861 g/cm³
• Vapor Pressure: 3.71E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 4.18±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE(14348-41-5)
• EPA Substance Registry System: 3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE(14348-41-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 14348-41-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

General Description

May contain up to 5.0 wt. % water

InChI:InChI=1/C7H5BrO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9H,(H,10,11)/p-1

Upstream product

• 60-29-7 diethyl ether 
• 89-55-4 5-bromosalicyclic acid 
• 925-90-6 ethylmagnesium bromide 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 99-96-7 4-hydroxy-benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 2315-86-8 3-bromo-4-hydroxybenzonitrile 
• 123-08-0 4-hydroxy-benzaldehyde 
• 106-44-5 p-cresol 
• 64-19-7 acetic acid 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 99-58-1 3-bromo-4-methoxybenzoic acid 
• 82906-07-8 2-bromo-4-dibromomethylphenol 

Downstream Products

• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 65145-77-9 4-octyloxy-3-bromo-benzoic acid 
• 37590-35-5 pentyl 3-bromo-4-hydroxybenzoate 
• 72415-57-7 4-acetoxy-3-bromo-benzoic acid 
• 79302-40-2 3-bromo-4-trimethylsiloxybenzoic acid trimethylsilyl ester 
• 79302-21-9 3-bromo-4-(trimethylsiloxy)benzoyl chloride 
• 946007-61-0 4-(benzyloxy)-3-cyanobenzoic acid 
• 556836-18-1 4-benzyloxy-3-cyanobenzoyl chloride 
• 1309921-08-1 ethyl 3-cyano-4-benzyloxybenzoate 
• 939051-02-2 ethyl 3-cyano-4-trifluoromethanesulfonyloxybenzoate 
• 1309921-12-7 ethyl 3-cyano-4-(1-naphthyl)benzoate 
• 1042333-64-1 2-cyano-3'-fluorobiphenyl-4-carboxylic acid 
• 1309921-13-8 C₁₄H₈FNO₂ 
• 1309921-14-9 C₁₈H₁₁NO₂ 

Relevant articles and documents

The Bromination of p-Hydroxybenzoic Acid in Aqueous Solution. Reaction via the Minor p-Carboxyphenoxide Anion Tautomer

The kinetics of bromination of p-hydroxybenzoic acid have been measured in aqueous solution in the pH range 0-6.From the pH-log rate profile the reactive species appear to be the free acid (pH 5).However, the reactivity attributable to the monoanion is about 9 times higher than that predicted by a Hammett plot for the bromination of p-substituted phenols.This deviation is described to reaction via the tautomeric p-carboxyphenoxide monoanion which is present to the extent of 1 in 3100.Support for this proposal comes from related studies on ethyl p-hydroxybenzate, 3-bromo-4-hydroxybenzoic acid, and p-methoxybenzoic acid.In particular, the 3-bromo-4-hydroxybenzoate anion appears to be 5200 times more reactive than predicted and twice as reactive as the p-hydroxybenzoate anion.These anomalies are removed if reaction occurs via the minor tautomeric anion.

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim]HSO4 Dedicated to my mentor Professor (Mrs.) Krishna Misra on her 76th birthday

Environmentally benign ionic liquid [bmim]HSO4 was found suitable for conversion of nitriles into carboxylic acids under mild conditions with excellent purity.

Regioselective and high-yielding bromination of phenols and anilins using N-bromosaccharin and amberlyst-15

A regioselective and facile conversion method for bromination of anilines and phenols using N-bromosaccharine in the presence of a catalytic amount of Amberlyst-15 lead to enhancement of the reaction rate and yielded brominated products in good to excellent yields and short reaction times.