117452-93-4Relevant academic research and scientific papers
Total Synthesis and Configurational Assignment of AscospiroketalA
Chang, Stanley,Hur, Soo,Britton, Robert
, p. 16646 - 16653 (2015)
The total synthesis of the marine fungus-derived natural product ascospiroketal is described. This concise synthesis relies on a unique AgI-promoted tandem cascade cyclization that provides direct access to the correctly configured tricyclic core of the natural product from a linear precursor. The synthesis of candidate stereostructures of ascospiroketalA allowed for the confident assignment of both the relative and absolute stereochemistry of this unusual octaketide.
Total synthesis of ascospiroketal a through a agI-promoted cyclization cascade
Chang, Stanley,Hur, Soo,Britton, Robert
, p. 211 - 214 (2015/03/04)
The total synthesis of four candidate stereostructures for the marine octaketide ascospiroketal A have been achieved. These concise and highly stereocontrolled syntheses feature a unique AgI-promoted cyclization cascade involving an oxetanyl ketochlorohydrin to access the entire tricyclic core of the natural product in one step. These syntheses also establish the full stereochemistry for the ascospiroketal natural products.
BIARYL COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 218, (2011/04/13)
Provided herein are compounds for treatment of KIT, CSF-1R and/or FLT3 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
