1174583-46-0Relevant academic research and scientific papers
Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II
Yang, Jee Sun,Song, Doona,Ko, Won Jin,Kim, Bunyea,Kim, Bo-Kyung,Park, Song-Kyu,Won, Misun,Lee, Kiho,Lee, Kyeong,Kim, Hwan Mook,Han, Gyoonhee
, p. 621 - 628 (2013)
A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.
