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BCECF-AM, also known as 2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein, is a cell-permeable ester of BCECF that, upon hydrolysis by cytosolic esterases, yields the intracellularly trapped pH-indicator BCECF. It is a widely-used fluorescent indicator for estimating intracellular pH and can be used to investigate intracellular changes in other ions, including potassium.
Used in Biomedical Research:
BCECF-AM is used as a fluorescent indicator for estimating intracellular pH in biomedical research. It allows simultaneous recording of cell volume changes and intracellular pH in single cells, making it a valuable tool for studying various cellular processes and mechanisms.
Used in Spectrofluorometry and Flow Cytometry:
BCECF-AM is used as a pH-sensitive dye in spectrofluorometry and flow cytometry for intracellular pH measurements. The pH-dependent ratio of emission intensity is determined when the dye is excited at different wavelengths (490 nm vs. 440 nm), providing a reliable method for assessing changes in intracellular pH.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, BCECF-AM could potentially be used in drug delivery systems to monitor the intracellular pH environment and optimize drug release or targeting.
Chemical Properties:
BCECF-AM is an isomeric mixture of lactones, acetates, and AM esters, and it appears as a pale yellow to yellow powder.

117464-70-7

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117464-70-7 Usage

Biological Activity

Non-charged, non-fluorescent pH indicator. Readily and rapidly diffuses through cell membranes.

Check Digit Verification of cas no

The CAS Registry Mumber 117464-70-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,4,6 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 117464-70:
(8*1)+(7*1)+(6*7)+(5*4)+(4*6)+(3*4)+(2*7)+(1*0)=127
127 % 10 = 7
So 117464-70-7 is a valid CAS Registry Number.

117464-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymet

1.2 Other means of identification

Product number -
Other names 2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester Mixed isomers

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:117464-70-7 SDS

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