1174655-38-9

Upstream product

• 81396-84-1 (2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 1174655-34-5 (2S,4R)-4-(tert-butyldimethylsilyloxy)-2-(6-fluoro-1H-indole-3-carbonyl)pyrrolidine-1-carboxylic acid benzyl ester 
• 1174655-37-8 [2S-(6-fluoro-1H-indole-3-carbonyl)-4S-(4'-nitrobenzoyloxy)pyrrolidin-1-yl]carboxylic acid benzyl ester 

Downstream Products

• 1260251-36-2 2-(6-fluoro-1H-indol-3-yl-d2-methyl)-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 1260251-23-7 [4S-acetoxy-2R-(6-fluoro-1H-indol-3-ylmethyl)pyrrolidin-1-yl]carboxylic acid benzyl ester 
• 1260251-25-9 {4S-acetoxy-2R-[3'-(4S-acetoxy-1-benzyloxycarbonylpyrrolidin-2R-ylmethyl)-6,6'-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-1-yl}carboxylic acid benzyl ester 
• 1260251-26-0 acetic acid 5-[3'-(4-acetoxypyrrolidin-2-ylmethyl)-6,6’-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-3-yl ester 
• 1260251-31-7 birinapant 
• 1260251-37-3 4-acetoxy-2-(6-fluoro-1H-indol-3-yl-d2-methyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1260251-24-8 C₄₆H₄₆F₂N₄O₈ 

Relevant academic research and scientific papers

Compound as apoptosis protein inhibitor, and application thereof

The present invention belongs to the field of medical chemistry, relates to a class of compounds of apoptosis protein inhibitors, and applications thereof, and particularly provides a compound represented by a formula I, or an isomer thereof, a pharmaceut

Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate

Birinapant/TL32711 (1) is a novel bivalent antagonist of the inhibitor of apoptosis (IAP) family of proteins which is currently in clinical development for the treatment of cancer and hepatitis B virus (HBV) infection. In this report, we present a detaile

SMAC MIMETIC (BIRINAPANT) FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES (CANCER)

A method of using a Smac mimetic and pharmaceutical compositions thereof.

SMAC Mimetic

A SMAC mimetic and pharmaceutical compositions thereof and methods of use.

IAP INHIBITORS

The present invention describes compounds of the following formula: processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. The compounds of the present invention inhibit IAPs (inhibitors of apoptosis protei