81396-84-1

Usage

Uses

Used in Organic Synthesis:
(2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid is used as a building block in organic synthesis for creating more complex molecules. Its multiple reactive functional groups allow for the development of a wide range of chemical structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid is used as a key intermediate in the synthesis of various drug molecules. Its chiral nature and functional groups make it a valuable component in the development of new pharmaceutical compounds.
Used in Materials Science:
(2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid is also used in materials science for the development of new materials with unique properties. Its complex structure and functional groups can contribute to the creation of advanced materials for various applications.
Used in Research and Development:
In research and development, (2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid is used as a subject of study for understanding its properties, reactivity, and potential applications. Researchers and chemists explore its behavior in various chemical reactions and its potential uses in different fields.

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 104197-68-4 (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 114358-14-4 O₁-benzyl O₂-methyl (2S,4R)-4-[tert-butyl(dimethyl)silyl]oxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 187525-60-6 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-phenylselanylcarbonyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 1438389-71-9 1-benzyloxycarbonyl-4-(R)-tert-butyldimethylsilyloxy-N-(p-butylbenzenesulfonyl)-2-(S)-pyrrolidinecarboxamide 
• 1174655-34-5 (2S,4R)-4-(tert-butyldimethylsilyloxy)-2-(6-fluoro-1H-indole-3-carbonyl)pyrrolidine-1-carboxylic acid benzyl ester 
• 1174655-35-6 (2S,4R)-2-(6-fluoro-1H-indol-3-carbonyl)-4-hydroxypyrrolidine-1-carboxylic acid benzyl ester 
• 1174655-37-8 [2S-(6-fluoro-1H-indole-3-carbonyl)-4S-(4'-nitrobenzoyloxy)pyrrolidin-1-yl]carboxylic acid benzyl ester 
• 1174655-38-9 [2S-(6-fluoro-1H-indole-3-carbonyl)-4S-hydroxypyrrolidin-1-yl]carboxylic acid benzyl ester 
• 1260251-22-6 [2R-(6-fluoro-1H-indol-3-ylmethyl)-4S-hydroxypyrrolidin-1-yl]carboxylic acid benzyl ester 
• 1260251-23-7 [4S-acetoxy-2R-(6-fluoro-1H-indol-3-ylmethyl)pyrrolidin-1-yl]carboxylic acid benzyl ester 
• 1260251-25-9 {4S-acetoxy-2R-[3'-(4S-acetoxy-1-benzyloxycarbonylpyrrolidin-2R-ylmethyl)-6,6'-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-1-yl}carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Harnessing Additional Capability from in Water Reaction Conditions: Aldol versus Knoevenagel Chemoselectivity

Aldol reaction chemoselectivity, racemic or enantioselective, has not been previously demonstrated in the presence of Knoevenagel active functional groups. Here, we show that unhindered β-diketones remain unreacted while a ketone moiety undergoes a highly

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransferase inhibitor.

Compound as apoptosis protein inhibitor, and application thereof

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Design, Synthesis, and Biological Evaluation of Peptidomimetic N-Substituted Cbz-4-Hyp-Hpa-Amides as Novel Inhibitors of Plasmodium falciparum

A new series of peptidomimetic N-substituted Cbz-4-Hyp-Hpa-amides were designed, synthesized, and evaluated for inhibition of the Plasmodium falciparum. Substituents on the N-atom of the amide group were selected alkyl-, allyl-, aryl-, 2-hydroxyethyl-, 2-

Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate

Birinapant/TL32711 (1) is a novel bivalent antagonist of the inhibitor of apoptosis (IAP) family of proteins which is currently in clinical development for the treatment of cancer and hepatitis B virus (HBV) infection. In this report, we present a detaile

SMAC MIMETIC (BIRINAPANT) FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES (CANCER)

A method of using a Smac mimetic and pharmaceutical compositions thereof.

Asymmetric Mannich reactions catalyzed by proline and 4-hydroxyproline derived organocatalysts in the presence of water

The ability of amphiphilic catalysts based on proline and 4-hydroxyproline to catalyze the Mannich reaction in aqueous media is reported. With a 4-tert-butyldimethylsiloxy-substituted organocatalyst derived from N-prolylsulfonamide, the reaction of cyclohexanone with iminoglyoxylate proceeds with high enantioselectivity (>99% ee for the syn-diastereomer). This catalyst was also successfully applied in a reaction of an iminoglyoxylate with an aqueous tetrahydro-2H-pyran-2,6-diol to give the corresponding 2,3-disubstituted tetrahydropyridine with up to 95:5 dr and 98% ee.

SMAC Mimetic

A SMAC mimetic and pharmaceutical compositions thereof and methods of use.

IAP INHIBITORS

The present invention describes compounds of the following formula: processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. The compounds of the present invention inhibit IAPs (inhibitors of apoptosis protei

A simple synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1-phenethyl- propylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl esters as novel cysteine protease inhibitors

A convenient synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1- phenethylpropylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl esters 17 and 18 as new cysteine protease inhibitors is described. The synthetic key strategies involve the diazocarbonyl insertion