1174665-95-2

Usage

Derivative of

Pyrazole

Contains

Benzyl group and carbonyl chloride functional group

Common use

Reagent in organic synthesis

Application

Preparation of pharmaceuticals and other fine chemicals

Versatility

Utilized in a variety of reactions to introduce the pyrazole carbonyl chloride moiety into organic molecules

Role

Building block in the synthesis of heterocyclic compounds, peptidomimetics, and other biologically active molecules

Reactivity and functionality

Valuable tool for synthetic chemists in the development of new compounds for various applications

Upstream product

• 100-39-0 benzyl bromide 
• 150559-94-7 ethyl 1‐benzyl‐1H‐pyrazole‐4‐carboxylate 
• 401647-24-3 1-benzyl-1H-pyrazole-4-carboxylic acid 

Downstream Products

• 1174665-92-9 5-(tert-butyl-dimethyl-silanyloxymethyl)-2-[5-{[1-(4-methyl-benzyl)-1H-pyrazole-4-carbonyl]-amino}-2-oxo-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-pyridin-3-yl]-indole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF

The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY

Compounds of formula (I) have checkpoint kinase 1 (CHK1 ) inhibitory activity: wherein R1, R2, R5 and R6 are independently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxymethyl, methoxy, triflu