1174673-74-5Relevant academic research and scientific papers
Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities
Palkowitz, Maximilian D.,Tan, Bo,Hu, Haitao,Roth, Kenneth,Bauer, Renato A.
, p. 2270 - 2273 (2017)
Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine.
Triton B-mediated mild, convenient, and efficient method for the selective alkylation of cyclic secondary amines and thiols
Meshram,Reddy, B. Chennakesava,Goud, P. Ramesh
experimental part, p. 2297 - 2303 (2009/12/01)
Alkylation of cyclic secondary amines, thiols, and pyridazinones has been demonstrated with alkyl halides using Triton B as base and reaction medium.
