1174717-98-6

Basic information

• Product Name: 2-(4-chlorophenyl)-4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester
• Synonyms: 2-(4-chlorophenyl)-4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester
• CAS NO: 1174717-98-6
• Molecular Weight: 334.783
• Mol File: 1174717-98-6.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester(1174717-98-6)
• EPA Substance Registry System: 2-(4-chlorophenyl)-4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester(1174717-98-6)

Safety Data

• Hazardous Substances Data: 1174717-98-6(Hazardous Substances Data)

Upstream product

• 1174717-97-5 5-(4-chlorophenyl)-2-ethoxyoxalyl-thiophene-3-ethyl formate 
• 95-92-1 oxalic acid diethyl ester 
• 100523-84-0 2-bromothiophene-4-carboxylic acid 
• 170355-38-1 5-bromo-3-thiophenecarboxylic acid ethyl ester 
• 88-13-1 3-Thiophene carboxylic acid 

Downstream Products

• 1174717-79-3 2-(4-chlorophenyl)-4-(3-furanmethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174717-76-0 2-(4-chlorophenyl)-4-(3-pyrrolemethyl56)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174717-82-8 2-(4-chlorophenyl)-4-(3-thiaphenemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174717-55-5 2-(4-chlorophenyl)-4-(3-pyridinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174717-64-6 2-(4-chlorophenyl)-4-(4-pyridinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174718-22-9 4-(3-furanmethyl)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazinyl-7-ethyl formate 
• 1174717-84-0 2-(4-chlorophenyl)-4-(2-pyrrolemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174717-63-5 2-(4-chlorophenyl)-4-(2-pyridinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174718-24-1 4-(2-pyrrolemethyl)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazinyl-7-ethyl formate 
• 1174717-40-8 2-(4-chlorophenyl)-4-(3-tetrahydrofuranmethy)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174717-43-1 2-(4-chlorophenyl)-4-(3-tetrahydrothiophenemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide 
• 1174718-23-0 4-(3-thiophenemethyl)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazinyl-7-ethyl formate 
• 1174718-21-8 4-(3-pyrrolemethyl)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazinyl-7-ethyl formate 
• 1174718-16-1 4-(3-pyridinemethyl)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazinyl-7-ethyl formate 

Relevant articles and documents

Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors

A novel series of CHK1 inhibitors based on thienopyridine template has been designed and synthesized. These inhibitors maintain critical hydrogen bonding with the hinge and conserved water in the ATP binding site. Several compounds show single digit nanomolar CHK1 activities. Compound 70 shows excellent enzymatic activity of 1 nM.

THIENOPYRIDAZINE COMPOUNDS, THEIR PREPARATIONS, PHARMACEUTICAL COMPOSITIONS AND USES

The present invention relates to thienopyridazine compounds of formula (I), their pharmaceutically acceptable salts or hydrates, wherein R1 and R2 are independently H or C1-4 alkyl, R3 is a saturated or unsaturated 5- or 6- membered ring containing N, S or O, or its optical isomers, R4 is a halophenyl monosubstituted or disubstituted at any position. The present invention provides the preparation methods of these compounds, pharmaceutical compositions containing these compounds and the uses of these compounds, particularly in treating cancer.

Novel Compounds and Therapeutic Use Thereof for Protein Kinase Inhibition

Novel compound having the following formula: Also disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chk1/Chk2.